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2023年7月1日
发表者 kimi1006
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TPC2 controls pigmentation by regulating melanosome pH and size

Melanin pigments are synthesized in skin and hair cells called melanocytes and provide color to skin and hair and protection against UV rays. Inadequate protection poses the risk of accumulating genetic mutations in the DNA of skin cells, which can lead to skin cancer. It can also reduce folate levels, which then causes birth defects. Therefore, understanding pigmentation is important for human health. There are several protein components of the machinery that regulates human pigmentation that work in unknown ways. Two-pore channel 2 (TPC2) is one of them. Here we found that TPC2 is located in compartments inside melanocytes known as melanosomes, where melanin is synthesized. TPC2 regulates the pH and size of melanosomes, thus controlling the amount of melanin produced. 继续阅读 →

2023年4月23日
发表者 kimi1006
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项目文章 | 单细胞测序刻画腭中缝膜内成骨模型 – 知乎

2022年11月，北京大学口腔医院国家口腔疾病临床医学研究中心联合首都医科大学附属北京儿童医院在学术期刊上发表题为“Midpalatal Suture: Single-Cell RNA-Seq Reveals Intramembrane Ossification and Piezo2Chondrogenic Mesenchymal Cell Involvement”的研究成果。文章首次使用单细胞测序深入研究了腭中缝区域，有助于建立腭中缝膜内成骨模型，并揭示了Piezo2+成软骨向间充质细胞在骨成熟和重塑过程中的潜在分子特征。 继续阅读 →

2023年4月8日
发表者 kimi1006
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Detection of the separated root canal instrument on panoramic radiograph: A comparison of LSTM and CNN deep learning methods

(14) (PDF) Detection of the separated root canal instrument on panoramic radiographAbstract and figuresObjectives:
A separated endodontic instrument is one of the challenging complications of root canal treatment. The purpose of this study was to compare two deep learning methods that are convolutional neural network (CNN) and long short-term memory (LSTM) to detect the separated endodontic instruments on dental radiographs. 继续阅读 →

2023年4月4日
发表者 kimi1006
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Potential functions of histone H3.3 lysine 56 acetylation in mammals

H3K56 acetylation (H3K56Ac) was first identified in yeast and has recently been reported to play important roles in maintaining genomic stability, chromatin assembly, DNA replication, cell cycle progression and DNA repair. Although H3.1K56Ac has been relatively well studied, the function of H3.3K56Ac remains mostly unknown in mammals. In this study, we used H3.3K56Q and H3.3K56R mutants to study the possible function of H3.3K56 acetylation. 继续阅读 →