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MicroRNA and AU-rich element regulation of prostaglandin synthesis – PMC

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RNA-binding protein-mediated regulation of this biological pathway.

Presence of 3′UTR AU-rich elements in prostaglandin pathway transcripts. The representation of the human mRNAs is not to scale. The filled triangles represent AU-rich sequences, AUUUA, contained within the 3′UTR; triangles adjacent to one another indicate multiple repeat elements. Identification of AU-rich elements was accomplished with AREsite (rna.tbi.univie.ac.at/cgi-bin/AREsite.cgi) [143] using the representative transcript containing the greatest number of AUUUA motifs although polyadenylation and splice variants can yield shortened 3′UTRs as observed with COX-1, COX-2, and EP3 mRNAs

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