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2023年4月27日
发表者 kimi1006
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如何挑选适合自己的含氟牙膏

含氟牙膏
主要成分:氟化物,如氟化钠、单氟磷酸钠及氟化亚锡。
含量:我国牙膏含氟量的国家标准为400-1500毫克/千克。
成年人的合适剂量在500-1500毫克/千克,产品包装上一般标为0.05%~0.15%
儿童牙膏中总含氟量0.05%~0.11%之间;

作用:氟化物可以促进牙本质的再矿化,并减少蛀牙的发生率。它能够与牙齿表面的钙磷质结合,形成更坚硬的物质,从而使牙齿更加耐受酸性环境的侵蚀。此外,含氟牙膏还可以减少口腔中的细菌数量,预防龋齿和牙龈疾病的发生。

中华口腔医学会推荐:防龋齿(蛀牙)要用含氟牙膏。(来源http://www.cndent.com/booksoforalhttps://c.xiumi.us/board/v5/25kFW/192560867
以下表格翻译自ADA2022年含氟牙膏使用指南。
年龄
刷牙说明
推荐牙膏使用
特别注意事项
低龋齿风险小朋友*
中高龋齿风险小朋友#
0-17个月
每天一至两次
开始教小朋友刷牙:吐出牙膏,不要吞咽
不使用牙膏
0.05%的儿童牙膏,米粒大小
18个月-6
每天两次
吐出牙膏,不要吞咽
含氟0.1%~0.15%牙膏
0.05%的儿童牙膏,绿豆大小
或者含氟0.1%~0.15%的含氟牙膏,米粒大小
6-12
每天至少两次
吐出牙膏,不要吞咽
含氟0.1%~0.15%牙膏
每天刷牙大于两次
13岁及以上
每天至少两次
吐出牙膏,不要吞咽
含氟0.1%~0.15%牙膏
每天刷牙大于两次
或者按照牙医专业推荐:使用高含氟0.5%的牙膏,每天两次
*低龋齿风险 居住在社区水氟化物区域。儿童:自身或父母/照顾者和兄弟姐妹中没有新的龋齿或非龋齿病变;成年人:没有以下中度或高度风险因素。改编自CAMBRAhttps://www.cdafoundation.org/Portals/0/pdfs/cambra_handbook.pdf
#中高龋齿风险因素 活跃的龋齿,氟化物暴露不足;高糖饮食;口腔卫生差 中;唾液分泌不足;未经治疗的龋齿的个人或家族病史;正在正畸治疗过程;其他个体因素,如低矿化牙齿,多种药物,特殊健康护理需求。

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2023年4月23日
发表者 kimi1006
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项目文章 | 单细胞测序刻画腭中缝膜内成骨模型 – 知乎

2022年11月,北京大学口腔医院国家口腔疾病临床医学研究中心联合首都医科大学附属北京儿童医院在学术期刊上发表题为“Midpalatal Suture: Single-Cell RNA-Seq Reveals Intramembrane Ossification and Piezo2Chondrogenic Mesenchymal Cell Involvement”的研究成果。文章首次使用单细胞测序深入研究了腭中缝区域,有助于建立腭中缝膜内成骨模型,并揭示了Piezo2+成软骨向间充质细胞在骨成熟和重塑过程中的潜在分子特征。

新格元在该研究中承担了组织保存与解离、单细胞转录组(GEXSCOPE®)测序以及单细胞数据生信分析等工作。

下面和元小新一起来看一下单细胞如何揭示腭中缝膜内成骨模型吧。

研究背景

腭中缝是上颌骨宽度生长发育的主要部位,也是对上颌宽度发育不足者进行上颌快速扩弓(RME)过程中阻抗的主要来源部位。探索腭中缝成熟骨化过程,阐明其中的潜在机制,有助于确定腭中缝RME的最佳时机与矫形力大小,临床意义重大。然而,与腭中缝相关的机制研究很少,目前腭中缝成熟骨化过程未见单细胞测序相关研究。

思维导图

研究结果

1.小鼠模型腭中缝的组织学染色和Micro-CT分析

随着周龄的增长,腭中缝的弯曲程度增加,4、5周龄时腭中缝形态较直,9周龄时较为弯曲。此外,从4周龄至9周龄,腭中缝宽度减小,骨密度(BMD)、骨体积/组织体积(BV/TV)明显增加。Micro-CT结果提示,随着腭中缝成熟骨化,其形态更加交错、宽度更窄,骨化程度增加,但需要注意的是,腭中缝在9周龄时仍未融合。组织学染色观察验证了Micro-CT分析结果,腭中缝区主要由纤维细胞、纤维和成骨细胞组成,在4周龄时观察到软骨细胞,但在5和9周龄时很少见。

图1 腭中缝的组织学染色及Micro-CT分析(小鼠模型)

2.小鼠模型腭中缝的单细胞RNA测序分析

利用单细胞RNA测序分析腭中缝区域的细胞和分子组成,质量控制后获得45,677个细胞,包括来自4周龄小鼠的16,686个细胞、来自5周龄小鼠的17,053个细胞、以及来自9周龄小鼠的11,938个细胞。确定了5种主要的细胞类型,包括上皮细胞、间充质细胞、免疫细胞、内皮细胞、以及神经细胞(图2A)。

由于间充质细胞在成熟骨化过程中,特别是在骨基质形成中作用至关重要,因此,从整体细胞群中选择间充质细胞进行进一步分析。结果表明间充质细胞由5个不同的簇组成,包括周细胞(标志基因为Acta2、Rgs5、Nes)、成骨向间充质细胞(标志基因为Ibsp、Mmp13、Bglap2)、成软骨向间充质细胞(标志基因为Col2a1、Col9a1、Col9a2、Ucma)、成纤维向间充质细胞(标志基因为Smoc2、Col8a1、Dpep1)、以及神经样细胞(标志基因为Olig2、Rtn1、Elavl4)(图2B)。

拟时序与RNA速率分析显示了各簇间充质细胞的分化轨迹,并进一步表明9簇间充质细胞处于不同的状态。在拟时序分析中,周细胞位于上支,成骨向间充质细胞-1(Ost.b1)位于两个下支,成骨向间充质细胞-2 (Ost.b2)和成骨向间充质细胞-3(Ost.b3)位于右下支,成纤维向间充质细胞-1、2、3(Fib.1、Fib.2、Fib.3)位于左下支(图2C)。RNA速率分析表明,虽然3个成骨向间充质细胞簇起始情况不同,但它们向相同的终点分化(图2D)。

图2 间充质细胞在腭中缝中显示出向成骨细胞、成软骨细胞和成纤维细胞方向分化的潜能

3.不同成骨向间充质细胞簇在腭中缝膜内成骨中的作用

为了描述腭中缝的成骨过程,对成骨向间充质细胞进行了差异表达基因(DEGs)和通路分析。Ost.b1的上调通路与间充质发育和血管生成相关,Ost.b2的上调通路与生物矿化和细胞外基质组织相关,Ost.b3的上调通路与组织重塑、软骨发育和破骨细胞分化相关(图3A、B)。4周龄的成骨向间充质细胞(Ost.b-4w)的上调通路与细胞增殖相关,Ost.b-5w的上调通路与破骨细胞和成骨细胞分化相关,Ost.b-9w的上调通路与软骨内骨形态发生相关(图3C、D)。

进一步分析三个关键时间点各细胞亚簇内成骨向间充质细胞的轨迹。结果表明,Ost.b1主要位于左侧支,Ost.b2主要位于右侧支,Ost.b3分布于左、右分支,这提示每个成骨向间充质细胞亚簇处于不同状态(图3E)。RNA速率分析验证了上述结果(图3F)。

图3 不同成骨向间充质细胞簇在腭中缝膜内成骨中发挥不同的作用

4.Piezo2+成软骨向间充质细胞的鉴定

由于软骨细胞在膜内成骨中可能发挥重要作用,因此,研究者进一步分析了腭中缝区成软骨向间充质细胞的数量、百分比与通路富集状态(图4A、B)。这些细胞中上调的通路与软骨凝集、结缔组织发育和机械刺激感受有关。对成软骨向间充质细胞与其他间充质细胞进行差异基因分析,发现了Piezo2基因的差异表达,这是一个与机械感觉离子通道相关的经典标记基因(图4C)。Piezo2基因的pct.1(0.35)与pct.2(0.037)差异较大,表明Piezo2是成软骨向间充质细胞的特异性基因(图4D)。

图4 scRNA-seq鉴定Piezo2+成软骨向间充质细胞

5.Piezo2+成软骨向间充质细胞可能与感受机械刺激与伤口愈合有关

接下来,研究者进行DEGs与通路富集分析,以明确Piezo2+Piezo2-成软骨向间充质细胞之间的转录差异(图5A、B)。与Piezo2-相比,Piezo2+成软骨向间充质细胞的机械刺激相关基因(Junb、Fos、lers)表达量更高,并且似乎与伤口愈合、对成纤维细胞生长因子的反应、间充质干细胞和软骨细胞分化等相关(图5C、D)。对Piezo2进行免疫组化染色,验证了Piezo2+成软骨向间充质细胞的存在,佐证了上述结果(图5E)。

图5 Piezo2+成软骨向间充质细胞与感受机械刺激有关

结论

为了探索腭中缝成熟骨化过程的潜在机制,本研究建立了一种小鼠腭中缝模型,结合经典的组织学染色分析、Micro-CT分析、以及前沿的单细胞测序分析,明确了腭中缝的细胞与分子组成。本研究首次使用单细胞RNA测序对腭中缝中的细胞群和成骨过程进行了表征,并发现了Piezo2+成软骨向间充质细胞群,提示间充质细胞有潜力参与腭中缝的成熟骨化过程。成骨向间充质细胞分为3个簇(Ost.b1、Ost.b2、Ost.b3),在膜内成骨过程中发挥多种作用。间充质细胞增殖、聚集(Ost.b1)、并分化为成骨细胞(Ost.b1、Ost.b2、Ost.b3);成骨细胞形成骨化中心,分泌类骨质,诱导骨矿化(Ost.b2),并转化为骨细胞;骨重建贯穿整个过程(Ost.b3)(图6)。此外,Piezo2+成软骨向间充质细胞可能与感受机械刺激有关,并有潜力在腭中缝成骨过程中发挥关键作用。总之,本文对腭中缝成熟骨化过程的研究具有创新性的重要意义。

图6腭中缝成熟骨化过程机制的示意图

参考文献

Lu Gao, Tiansong Xu , Liqi Zhang,et al. Midpalatal Suture: Single-Cell RNA-Seq Reveals Intramembrane Ossification and Piezo2 Chondrogenic Mesenchymal Cell Involvement.2022 Nov 12;11(22):3585.

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2023年4月23日
发表者 kimi1006
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Nature |首次发现介导膜内成骨的骨膜干细胞,解决了困扰领域内长久的膜内成骨/软骨成骨化的干细胞归属问题-微信文章-仪器谱

撰文丨许韧 博士

责编丨迦溆

组织特异性干细胞的鉴定和分化成熟,一直以来都是各器质类疾病研究和癌症发生中的经典问题,决定了药物开发和诊疗策略的方向。长久以来,骨骼研究学者们也一直聚焦于骨髓微环境的干细胞分化“事件”:间充质干细胞分化的成骨细胞和造血干细胞由来的破骨细胞所介导的骨代谢平衡。然而,相比较于研究透彻的造血干细胞系统,间充质干细胞特别是成骨干细胞的鉴定和分化研究,一直以来仍处于相对空白或滞后的状态,成为了深入骨骼和相关疾病研究的“瓶颈”

近年来,随着单细胞测序技术和共聚焦显微成像的发展和运用,髓内间充质干细胞的鉴定和功能解析逐渐成为学科内新的研究热点。2015年, 斯坦福大学Michael T. Longaker研究团队首次在Cell杂志上发文【1】,系统性阐明了小鼠骨骼干细胞的富集策略和“干”性鉴定,解决了困扰学术界以久的成骨干细胞的定义问题。同期,哥伦比亚大学的Timothy C. Wang团队也于Cell报道了Gremlin1 标记的骨骼干细胞的分化潜能【2】。这两项背靠背的研究吹响了骨骼干细胞研究的号角。近期,Michael T. Longaker课题组更是开创性地鉴定了人类骨骼干细胞及其分化的等级关系【3】Cell突破丨人类骨骼干细胞终于被鉴定出来,为骨骼疾病的精准治疗奠定了分子遗传和发育的理论基础,预示着一场硬组织干细胞的研究“风暴”即将来临。

图一 经典骨骼形态解剖学

经典骨骼形态解剖学显示骨骼系统被皮质骨天然隔离成骨腔内环境和骨膜外环境(如图一)。然而,长久以来,骨生物学家们一直专注于髓内多能干细胞的功能和临床运用,却忽略了骨膜潜在的干细胞属性。试验和临床上的大量数据表明,骨骼系统的发育和再生与其包被的骨膜有着千丝万缕的联系, 例如骨折的愈合和促骨形成药物的响应等。既然骨膜的功能在生理和病理条件下都如此重要,那么骨膜中的成骨干细胞是否存在?如果存在,它的分化等级和功能又是如何呢?其实早在2013年,布朗大学的Wentian Yang研究团队就已经在Nature发文证实,在关节软骨外膜旁的兰氏结构处(perichondrial groove of Ranvier),存在着一些cathepsin K阳性的 类似间质干细胞的分布【4】。文章进一步显示在小鼠的cathepsin K阳性细胞中,敲除Ptpn11会导致内生软骨瘤的形成,潜在证明了cathepsin K不仅仅标记成熟的破骨细胞而且很有可能标记骨膜中的成骨前体细胞或干细胞。

近期,骨膜干细胞的神秘面纱终于被揭开,来自于美国康奈尔大学威尔医学院的Matthew B. Greenblatt研究团队在Nature杂志发表了题为Discovery of a periosteal stem cell mediating intramembranous bone formation的研究快报,首次发现了骨膜干细胞并鉴定了其内成骨的特性,解决了困扰领域内以久的膜内成骨/软骨成骨化的干细胞归属问题。

图二 骨膜上间质干细胞来源的细胞

该课题组首先运用Cathepsin K cre 小鼠为主要模型,通过与Rosa-Mt/Mg 小鼠的交配,在体内建立了Cathepsin K cre 阳性细胞的“可视化”体系。共聚焦免疫荧光成像显示Cathepsin K 除了标记成熟的破骨细胞外,的确也可以标记部分骨膜上间质干细胞来源的细胞(图二),这与2013 年Nature论文(Wentian Yang et.al)关于的发现Cathepsin K cre 阳性细胞的描述所一致。接着, 作者安排了最关键一步的试验设计,通过鉴定小鼠骨骼干细胞的流式细胞分离方法,发现Cathepsin K 阳性骨膜细胞囊括了骨骼干细胞(CD200+CD105-);骨,软骨,基质祖细胞(CD200-CD105-)和骨,软骨,基质前体细胞(CD200-CD105+)三大阶层。更为有意思的是:Cathepsin K 阳性骨膜干细胞不表达髓内间充质谱系细胞的经典标记蛋白(CD146;PDGF-alpha;Leptin receptor)。此外,骨膜干细胞还大量富集于小鼠新生颅骨的嵌合位置,暗示其主要作用于膜内成骨而非软骨成骨。

图三 单细胞测序验证骨膜干细胞

针对如此特异的Cathepsin K 阳性骨膜干细胞,作者谨慎地运用了一系列经典的干细胞鉴定策略去进一步深入肯定其“干”性。

1.在体外,对骨膜干细胞进行不同分化诱导培养,确定了其生成骨骼、软骨、脂肪的多重潜能;

2. 在体内,将骨膜干细胞移植到肾脏囊腔或是乳腺脂肪层中,进一步确定了其专属的成骨特性-膜内成骨;

3.也是最为关键的一步,将移植肾脏中的类骨形成物(GFP标记)进行再次流式细胞分离,得到的干细胞进行二次移植,肯定了其干细胞可以持续更新和再分化成不同阶层的特性(干细胞的金标准)。紧接着,也是该篇文章的画龙点睛之笔(个人认为也是深受Nature钟爱的特性之一)作者运用了单细胞测序的新技术和最新生信解析方法(图三),进一步客观验证了骨膜干细胞的存在以及和其他谱系细胞的发育关联。

图四 骨折模型中验证了骨损伤诱导了Cathepsin K阳性细胞的扩增

最后,作者通过生理和病理模型肯定了Cathepsin K标记的骨膜干细胞在骨形成和再生中的功用。首先,通过敲除破骨细胞非表达的Osx基因确定了Cathepsin K阳性细胞在皮质骨生成中的特殊功用,并不影响到松质骨的累积。接着,在骨折模型中验证了骨损伤诱导了Cathepsin K阳性细胞的扩增,缺失成骨功能的Cathepsin K阳性细胞会直接导致骨折愈合不连(图四)。最后,作者进一步在人类的骨膜组织中也发现了与小鼠模型类似的Cathepsin K阳性骨膜干细胞并验证了其专属膜内成骨的特性。

总体上来说,该项工作的论述简洁明快,切入点新颖准确,针对骨骼发育中的核心问题:膜内成骨化和软骨成骨化的归属问题,巧妙借鉴前人的研究发现和方法,融合当前最热的技术门类,解答了困扰学术界多年以来的基本问题,值得大家思考和学习。本工作的通讯作者为Matthew B. Greenblatt 博士,康奈尔大学威尔医学院独立PI,是骨骼生物学领域近年来涌现的青年才俊之一。

参考文献:

1、Chan, C. K., Seo, E. Y., Chen, J. Y., Lo, D., McArdle, A., Sinha, R., … & Lu, W. J. (2015). Identification and specification of the mouse skeletal stem cell. Cell, 160(1), 285-298.

2、Worthley, D. L., Churchill, M., Compton, J. T., Tailor, Y., Rao, M., Si, Y., … & Gross, S. (2015). Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential. Cell, 160(1), 269-284.

3、Chan, C. K., Gulati, G. S., Sinha, R., Tompkins, J. V., Lopez, M., Carter, A. C., … & Brewer, R. E. (2018). Identification of the Human Skeletal Stem Cell. Cell, 175(1), 43-56.

4、Yang, W., Wang, J., Moore, D. C., Liang, H., Dooner, M., Wu, Q., … & Neel, B. G. (2013). Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling. Nature, 499(7459), 491.


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2023年4月18日
发表者 kimi1006
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Nature | 鉴定出对anti-PD1治疗有反应性的肿瘤抗原特异性CD8+T细胞

撰文 | 雪月

肿瘤抗原是由非同义突变导出的多肽,由人类白细胞抗原(human leukocyte antigens,HLA呈递,从而被抗肿瘤T细胞识别。但是 HLA等位基因的多样性和临床样本的限制阻碍了针对抗原靶向T细胞谱的研究。

近日,来自加州大学洛杉矶分校的Antoni Ribas 团队在Nature 上发表题为Neoantigen-targeted CD8+ T cell responses with PD-1 blockade therapy 的文章。该文章建立了发现肿瘤抗原特异性T细胞的方法,并对比了抗PD-1治疗有反应和无反应患者的CD8+T细胞中针对肿瘤抗原的TCR类型。


作者认为在分析免疫检查点阻断剂(immune checkpoint blockade ICB治疗诱导的肿瘤抗原特异性T细胞反应谱需要高灵敏度的方法,能够在相对较少的患者样本中检测到数百个肿瘤抗原特异性T细胞反应。这些样本包含了从肿瘤活检中扩增的数百万外周血单个核细胞PBMCs浸润肿瘤的淋巴细胞TILs。新方法需要提高重建分离的肿瘤抗原特异性T细胞受体neoTCRs的抗原特异性的效率。最后还需要评估靶向肿瘤抗原的T细胞的识别以及抗肿瘤活性,用于评估的细胞系需表达突变的肿瘤抗原。满足以上条件将允许分析肿瘤抗原特异性T细胞反应谱。

作者首先收集了11名接受anti-PD1治疗的转移性黑色素瘤患者不同时间点的外周血单核细胞,并且从患者的肿瘤活检样本中建立了肿瘤浸润淋巴细胞培养系和自体肿瘤细胞系。作者对肿瘤活检样本进行全外显子测序和转录组分析,并与相匹配的PBMC的DNA进行比对。这些数据可以用来检测每位患者的6个HLA I类等位基因,检测出特异性的非同义突变,对HLA I类分子递呈推断的肿瘤抗原进行预测。作者对每个患者中的肿瘤抗原肽-HLA进行了优先排序。肽-HLA复合物文库在HEK293细胞中合成,并对蛋白质文库进行DNA条形码编码和荧光多聚化。将文库和患者的PBMC或者从肿瘤活检样本中扩增的淋巴细胞进行孵育,然后将肿瘤抗原特异性T细胞通过单细胞分选捕获,通过条形码分析T细胞的抗原特异性,从而定义抗肿瘤CD8+T细胞识别的突变肿瘤抗原。作者用这种方法分析了11个病人,其中7个对抗PD-1治疗有反应。作者发现抗PD-1治疗有反应的患者的非同义突变数量较高。在分离了肿瘤抗原特异性T细胞后,作者进行了单细胞TCR测序,在抗PD-1治疗有反应的患者中,靶向突变的TCR类型要高于无反应性的患者。作者挑选了22个neoTCR,克隆表达在健康个体来源的T细胞中以验证功能。分析发现在肿瘤抗原-HLA复合物刺激下,表达neoTCR的T细胞会分泌IFNg IL2和TNF。用同样方法进一步分析对抗PD-1无反应的患者,作者发现这些个体中也有肿瘤抗原特异性T细胞,当这些TCR表达在健康个体来源T细胞中也能够对自体肿瘤细胞系产生效应。这些有可能用于个性化细胞转移疗法。

本研究表明抗PD-1免疫疗法的反应性与肿瘤和外周血中多克隆CD8+T细胞的存在相关。新建立的发现肿瘤抗原特异性T细胞的方法有助于改进免疫治疗效果。

原文链接:
https://doi.org/10.1038/s41586-023-05787-1

制版人:十一


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2023年4月16日
发表者 kimi1006
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Cell | 历经13年!破除争议:不是基因突变!表观遗传信息的丢失是衰老的主要驱动因素


iNature

所有生物都经历了熵的增加,表现为遗传和表观遗传信息的损失。在酵母中,随着时间的推移,由于染色质修饰蛋白对DNA断裂的重新定位,导致细胞失去了它们的身份,这是酵母衰老的标志。
2023年1月12日,哈佛医学院David A. Sinclair团队在Cell 在线发表题为“Loss of epigenetic information as a cause of mammalian aging”的研究论文,该研究使用一种称为“ICE”(inducible changes to the epigenome,表观基因组诱导变化)的系统,发现表观遗传信息的紊乱导致小鼠衰老,而恢复表观基因组的完整性可以逆转衰老的迹象。

总之,这些数据与衰老的信息论是一致的,该理论认为表观遗传信息的丢失是衰老的可逆原因。

生命是基于细胞机制和存储在基因组和表观基因组中的信息之间复杂的相互作用,这可以被认为是生物“硬件”和“软件”。衰老是由“硬件”故障引起的,还是由“软件”故障引起的,还是两者都造成的,目前还不清楚。在20世纪50年代,Szilard及Medawar分别独立提出衰老是由DNA损伤引起的突变导致遗传信息丢失引起的。与衰老最相关的DNA损伤类型是双链DNA断裂(DSB),以每个细胞每天10-50次的速度发生。
然而,最近,关于基因突变是否是衰老的首要驱动因素的问题被提出了。许多类型的老细胞缺乏突变,具有较高突变率的小鼠或人的品系几乎没有显示出过早衰老的证据,哺乳动物可以从旧体细胞克隆出具有正常寿命的新个体。在发育过程中,细胞的身份是由转录网络和染色质结构指定的。为了保持最佳功能,细胞必须通过保存表观遗传信息和低熵状态来保持其身份。
文章模式图(图源自Cell
表观遗传信息的丢失,而不是遗传,作为衰老的潜在原因,出现在20世纪90年代的酵母研究中。沉默信息调节复合物(Sir2/3/4)从沉默交配型位点重新定位到不稳定的rDNA是不育的原因,这是酵母衰老的标志,与组蛋白占用的改变、组蛋白修饰(例如H3K56ac和H4K16ac)和基因转录一致。SIR2、组蛋白的过表达或组蛋白甲基转移酶基因SET2的缺失延长了酵母的寿命,这表明表观遗传变化不仅是一种生物标志物,而且是酵母衰老的原因。
与衰老相关的表观遗传变化,包括DNA甲基化(DNAme)模式的变化,H3K4me3, H3K9me3和H3K27me3,也可见于多细胞生物中。例子包括缺乏H3K4三甲基化复合物的蠕虫或过度表达Sir2基因的果蝇的寿命延长,以及长寿裸鼹鼠的相对稳定的表观基因组。许多表观遗传变化遵循特定的模式,包括表观遗传时钟的特定CpGs的甲基化。
哺乳动物表观基因组随时间变化的原因尚不清楚。线索还是来自酵母。酵母中的一个主要驱动因素是DSB,其修复需要表观遗传调控因子Sir2, Hst1, Rpd3, Gcn5和Esa1。染色质修饰剂的重新定位或“RCM”假说和随后的“衰老的信息论”提出,真核生物的衰老是由于转录网络和表观遗传信息随着时间的推移而丢失,由一种保守机制驱动,该机制进化为共同调节对细胞损伤的反应,如DSB或挤压损伤。
为了测试表观遗传变化是否是哺乳动物衰老的原因,该研究开发了系统来降解和重置细胞和小鼠的表观遗传信息。该研究的数据表明,哺乳动物的衰老相当于“软件”问题,是表观遗传信息损坏的结果,可以从现有的备份副本中恢复。
“该研究历经13年,我们相信我们的研究是第一个表明表观遗传变化是哺乳动物衰老的主要驱动因素的研究,”该论文的通讯作者、哈佛医学院David Sinclair说。该团队广泛的一系列实验证实了人们期待已久的事实:DNA变化不是衰老的唯一原因,甚至不是主要原因。相反,研究结果表明,染色质的化学和结构变化在不改变遗传密码本身的情况下加速衰老。

参考消息:
https://www.cell.com/cell/fulltext/S0092-8674(22)01570-7
https://medicalxpress.com/news/2023-01-loss-epigenetic-aging-reverse.html

END

内容为【iNature】公众号原创,

转载请写明来源于【iNature】

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2023年4月8日
发表者 kimi1006
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transwell细胞计数

Automatic Cell Counter

What is this?

This repository provides an automatic cell counter algorithm to count cell numbers in 2D microscopy images from Boyden Chamber assay and offers a user interface for further manual correction.

Please star this repository if you like it 🙂

Installation:

This algorithm has been implemented using Python 3.9. To install the necessary packages for this framework run:

pip install -r requirements.txt

If you are using conda first install pip by: conda install pip

Usage:

To run the cell counter, the user can easily input the following code in the terminal.

Require arguments:

  • -image: The path of the input image or the path of the directory.
python viewer.py --image example_data/8.tif

or

python viewer.py --image example_data/

Here is a tutorial to set up your Automatic Cell Counter for Windows: Tutorial

Example output:

The user interface will be built based on every input image for manual correction. Inside each image, red dots are used to denote the centers of the detected cells. We also used green dots and red bounding boxes to guide users to pay more attention to those easy-to-make-mistake areas: green dots (detected cells are quite small, perhaps one cell is divided to several parts) and red bounding box (high density areas, perhaps two cells are merged). The user may add dots or delete dots manually based on the automatically detected results.

After manual correction, press the ‘d’ (denotes Done) key on the keyboard to print the updated cell numbers on the terminal and close the current window. When all images are corrected, an excel file named result will be generated which contains both automatically detected cell numbers and corrected cell numbers.

User interface for manual correction:

Example output on the terminal (left) and in the excel (right):

Data:

The target images for this reporsitory are taken from Boyden Chamber assay under the microscope – Brightfield, 20x. The assay is based on a chamber of two medium-filled compartments separated by a microporous membrane. The cells are placed on the top of the chamber and are allowed to migrate/invade through the pores of the membrane into the lower compartment. After a certain time, the cells are fixed and stained with 0.05% Crystal Violet – and the number of cells into the lower compartment are counted to determine the migratory or invading capacity of the cells.

The parameters of this algorithm are determined for image with size of 1550 * 2088. If your images are much smaller or larger than this size, please adjust the parameters.

Example images:

Methods:

How to cite:

@software{ruolin_shen_2022_6390980,
  author       = {Ruolin Shen and
                  Christina Bukas and
                  Marie Piraud},
  title        = {{HelmholtzAI-Consultants-Munich/Automatic-Cell- 
                   Counter: First version of the software}},
  month        = mar,
  year         = 2022,
  publisher    = {Zenodo},
  version      = {v1.0.0},
  doi          = {10.5281/zenodo.6390980},
  url          = {https://doi.org/10.5281/zenodo.6390980}
}
Measure
Measure

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2023年4月8日
发表者 kimi1006
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Detection of the separated root canal instrument on panoramic radiograph: A comparison of LSTM and CNN deep learning methods

(14) (PDF) Detection of the separated root canal instrument on panoramic radiograph

Abstract and figures
Objectives:
A separated endodontic instrument is one of the challenging complications of root canal treatment. The purpose of this study was to compare two deep learning methods that are convolutional neural network (CNN) and long short-term memory (LSTM) to detect the separated endodontic instruments on dental radiographs.
Methods:
Panoramic radiographs from the hospital archive were retrospectively evaluated by two dentists. A total of 915 teeth, of which 417 are labeled as “separated instrument” and 498 are labeled as “healthy root canal treatment” were included. A total of six deep learning models, four of which are some varieties of CNN (Raw-CNN, Augmented-CNN, Gabor filtered-CNN, Gabor-filtered-augmented-CNN) and two of which are some varieties of LSTM model (Raw-LSTM, Augmented-LSTM) were trained based on several feature extraction methods with an applied or not applied an augmentation procedure. The diagnostic performances of the models were compared in terms of accuracy, sensitivity, specificity, positive and negative predictive value using ten-fold cross-validation. A McNemar’s tests was employed to figure out if there is a statistically significant difference between performances of the models. Receiver Operating Characteristic (ROC) curves were developed to assess the quality of the performance of the most promising model (Gabor filtered-CNN model) by exploring different cut-off levels in the last decision layer of the model.
Results:
The Gabor filtered-CNN model showed the highest accuracy (84.37 ± 2.79), sensitivity (81.26 ± 4.79), positive predictive value (84.16 ± 3.35) a​n​
… 
Figure content uploaded by Cansu Buyuk
Author content
Content may be subject to copyright.
Content uploaded by Cansu Buyuk
Author content
Content may be subject to copyright.
Page 1
birpublications.org/dmfrDentomaxillofacial Radiology (2023) 0, 20220209© 2023 The Authors. Published by the British Institute of RadiologyRESEARCH ARTICLEDetection of the separated root canal instrument on panoramicradiograph: a comparison of LSTM and CNN deeplearning methods1Cansu Buyuk, 2Burcin Arican Alpay and 3Fusun Er1Department of Dentomaxillofacial Radiology, Istanbul Okan University, Faculty of Dentistry,İstanbul, Turkey; 2Department ofEndodontics, Bahcesehir University, Faculty of Dentistry,İstanbul, Turkey; 3Information Systems Engineering, Piri Reis University,Faculty of Engineering,İstanbul, TurkeyObjectives:A separated endodontic instrument is one of the challenging complications of rootcanal treatment. The purpose of this study was to compare two deep learning methods that areconvolutional neural network (CNN) and long short-term memory (LSTM) to detect the separatedendodontic instruments on dental radiographs.Methods:Panoramic radiographs from the hospital archive were retrospectively evaluated by twodentists. A total of 915 teeth, of which 417 are labeled as “separated instrument” and 498 are labeledas “healthy root canal treatment” were included. A total of six deep learning models, four of whichare some varieties of CNN (Raw-CNN, Augmented-CNN, Gabor filtered-CNN, Gabor-filtered-augmented-CNN) and two of which are some varieties of LSTM model (Raw-LSTM, Augmented-LSTM) were trained based on several feature extraction methods with an applied or not applied anaugmentation procedure. The diagnostic performances of the models were compared in terms ofaccuracy, sensitivity, specificity, positive- and negative-predictive value using 10-fold cross-validation.A McNemar’s tests was employed to figure out if there is a statistically significant difference betweenperformances of the models. Receiver operating characteristic (ROC) curves were developed toassess the quality of the performance of the most promising model (Gabor filtered-CNN model) byexploring different cut-off levels in the last decision layer of the model.Results:The Gabor filtered-CNN model showed the highest accuracy (84.37 ± 2.79), sensitivity(81.26 ± 4.79), positive-predictive value (84.16 ± 3.35) and negative-predictive value (84.62 ± 4.56with a confidence interval of 80.6 ± 0.0076. McNemar’s tests yielded that the performance of theGabor filtered-CNN model significantly different from both LSTM models (p< 0.01).Conclusions:Both CNN and LSTM models were achieved a high predictive performance onto distinguish separated endodontic instruments in radiographs. The Gabor filtered-CNN modelwithout data augmentation gave the best predictive performance.Dentomaxillofacial Radiology(2023)0, 20220209. doi: 10.1259/dmfr.20220209Cite this article as:Buyuk C, Arican Alpay B, Er F. Detection of the separated root canalinstrument on panoramic radiograph: a comparison of LSTM and CNN deep learningmethods.Dentomaxillofac Radiol(2023) 10.1259/dmfr.20220209.Keywords:Artificial intelligence; CNN; deep learning; LSTM; panoramic radiograph; sepa-rated endodontic instrumentsIntroductionThe common causes offailure in endodontic treat-ments are the persistence of bacteria, inadequate rootcanal filling, poor obturation quality, microleakage, andcomplications ofinstrumentation such as separatedendodontic instruments (SEI).1 The incidence of theSEI in the root canal was reported to range from 0.4 to7.4%.2 In teeth with a SEI, the success of retreatmentCorrespondence to: Cansu Buyuk, E-mail: cansubuyuk@yahoo.comReceived 14 June 2022; revised 08 December 2022; accepted 05 January 2023;published online 24 January 2023
Similar research
Objectives: Dentists rely on radiographs in making treatment decisions everyday. However, if inattentively read, radiographs can lead to over or under-treatment. In this poster we present the results of a pilot study related to automated detection of apical radiolucencies using a deep learning software. Our main objectives are:-Assessing the diagnostic performance of a computer-aided deep learning detection system at detecting apical radiolucencies (AR) on periapical radiographs.-Evaluating the diagnostic performance of three board-certified experts in OMF Radiology and Endodontics for the same task.-Comparing the performance metrics of the deep leaning software and expert observers. Methods: The UNC Adams School of Dentistry-OMFR CBCT referral database was searched for all cone beam volumes acquired for Endodontic purposes from 08/25/2014 to 3/24/2019.The search criteria included endodontically treated and untreated teeth that exhibited apical radiolucencies on CBCT and had a diagnostically-acceptable intraoral image for the same site; acquired no more than 6 months apart. All patients were above 18 years of age. The search yielded 184 positive intraoral images which were de-identified and uploaded to the diagnostic software. Positive images where used to create a training set (54 images) and a testing set (130 images). Both sets were annotated for AR using the ground truth cone beam volume. An additional 132 intraoral images without apical radiolucencies were uploaded to serve as controls. The training and testing sets did not overlap. Seventy images were randomly selected from the negative and positive testing sets for the purpose of this pilot. Three expert-observers were calibrated and asked to view and annotate the pilot testing set independently. A (1-5) Likert scale to indicate level of confidence was used. Results: The standalone software performance (by tooth) results were as follows: sensitivity was 93%, specificity was 88% while ROC-AUC was 94% (95%CI: 89%,-98%). Whereas the experts combined performance results were as follows: sensitivity was 87%, specificity was 97% while ROC-AUC was 93% (95%CI: 88%,-98%). Notably, sensitivity varied by location of the radiolucency in the arch. The software performance metrics were lowest in the maxillary posterior region. Conclusions: Using a limited testing dataset, AI provided comparable performance to expert observers for this task. Further AI training is necessary to increase the sensitivity and specificity of AR detection in the posterior maxillary region. In Dentistry, multiple AI diagnostic software and tools have emerged recently for the assessment of dental caries. Additionally, neural networks and deep learning algorithms have been utilized in predicting dental pain, teeth numbering and classification, in deciding if extractions are necessary prior to orthodontic treatment and in evaluating factors affecting the diagnosis and final treatment outcomes of impacted maxillary canines. The need for AI and automation is largely linked to the anticipated increase in accuracy and speed, leading to an improved workflow and efficiency of resources. (1,2)
While a large number of archived digital images make it easy for radiology to provide
data for Artificial Intelligence (AI) evaluation; AI algorithms are more and more applied in detecting
diseases. The aim of the study is to perform a diagnostic evaluation on periapical radiographs with an
AI model based on Convoluted Neural Networks (CNNs). The dataset includes 1169 adult periapical
radiographs, which were labelled in CranioCatch annotation software. Deep learning was performed
using the U-Net model implemented with the PyTorch library. The AI models based on deep learning
models improved the success rate of carious lesion, crown, dental pulp, dental filling, periapical
lesion, and root canal filling segmentation in periapical images. Sensitivity, precision and F1 scores
for carious lesion were 0.82, 0.82, and 0.82, respectively; sensitivity, precision and F1 score for crown
were 1, 1, and 1, respectively; sensitivity, precision and F1 score for dental pulp, were 0.97, 0.87 and
0.92, respectively; sensitivity, precision and F1 score for filling were 0.95, 0.95, and 0.95, respectively;
sensitivity, precision and F1 score for the periapical lesion were 0.92, 0.85, and 0.88, respectively;
sensitivity, precision and F1 score for root canal filling, were found to be 1, 0.96, and 0.98, respectively.
The success of AI algorithms in evaluating periapical radiographs is encouraging and promising for
their use in routine clinical processes as a clinical decision support system.
  • January 2023
  • Computational and Mathematical Methods in Medicine
Aim:
This comprehensive review is aimed at evaluating the diagnostic and prognostic accuracy of artificial intelligence in endodontic dentistry.

Introduction:
Artificial intelligence (AI) is a relatively new technology that has widespread use in dentistry. The AI technologies have primarily been used in dentistry to diagnose dental diseases, plan treatment, make clinical decisions, and predict the prognosis. AI models like convolutional neural networks (CNN) and artificial neural networks (ANN) have been used in endodontics to study root canal system anatomy, determine working length measurements, detect periapical lesions and root fractures, predict the success of retreatment procedures, and predict the viability of dental pulp stem cells. Methodology. The literature was searched in electronic databases such as Google Scholar, Medline, PubMed, Embase, Web of Science, and Scopus, published over the last four decades (January 1980 to September 15, 2021) by using keywords such as artificial intelligence, machine learning, deep learning, application, endodontics, and dentistry.

Results:
The preliminary search yielded 2560 articles relevant enough to the paper’s purpose. A total of 88 articles met the eligibility criteria. The majority of research on AI application in endodontics has concentrated on tracing apical foramen, verifying the working length, projection of periapical pathologies, root morphologies, and retreatment predictions and discovering the vertical root fractures.

Conclusion:
In endodontics, AI displayed accuracy in terms of diagnostic and prognostic evaluations. The use of AI can help enhance the treatment plan, which in turn can lead to an increase in the success rate of endodontic treatment outcomes. The AI is used extensively in endodontics and could help in clinical applications, such as detecting root fractures, periapical pathologies, determining working length, tracing apical foramen, the morphology of root, and disease prediction.

Technological advancements in health sciences have led to enormous developments in artificial intelligence (AI) models designed for application in health sectors. This article aimed at reporting on the application and performances of AI models that have been designed for application in endodontics. Renowned online databases, primarily PubMed, Scopus, Web of Science, Em-base, and Cochrane and secondarily Google Scholar and the Saudi Digital Library, were accessed for articles relevant to the research question that were published from 1 January 2000 to 30 Novem-ber 2022. In the last 5 years, there has been a significant increase in the number of articles reporting on AI models applied for endodontics. AI models have been developed for determining working length, vertical root fractures, root canal failures, root morphology, and thrust force and torque in canal preparation; detecting pulpal diseases; detecting and diagnosing periapical lesions; predicting postoperative pain, curative effect after treatment, and case difficulty; and segmenting pulp cavities. Most of the included studies (n = 21) were developed using convolutional neural networks. Among the included studies. datasets that were used were mostly cone-beam computed tomography images , followed by periapical radiographs and panoramic radiographs. Thirty-seven original research articles that fulfilled the eligibility criteria were critically assessed in accordance with QUADAS-2 guidelines, which revealed a low risk of bias in the patient selection domain in most of the studies (risk of bias: 90%; applicability: 70%). The certainty of the evidence was assessed using the GRADE approach. These models can be used as supplementary tools in clinical practice in order to expedite the clinical decision-making process and enhance the treatment modality and clinical operation.
The aim of this study was to develop a deep learning model to automatically detect and segment unobturated mesial buccal 2 (MB2) canals on endodontically obturated maxillary molars depicted in CBCT studies. Fifty-seven deidentified CBCT studies of maxillary molars with clinically confirmed unobturated MB2 canals were retrieved from a dental institution radiology database. One-hundred and two maxillary molar roots with and without unobturated MB2 canals were segmented using ITK-SNAP. The data were split into training and testing samples designated to train and evaluate the performance, respectively, of a convolutional neural network (CNN), U-Net. The detection performance revealed a sensitivity of 0.8, a specificity of 1, a high PPV of 1, and a NPV of 0.83 for the testing set, along with an accuracy of 0.9. The segmentation performance of unobturated MB2 canals, assessed using the custom metric, rendered a mean value of 0.3018 for the testing set. The current AI algorithm has the potential to identify obturated and unobturated canals in endodontically treated teeth. However, the AI algorithm is still somewhat affected by metallic artifacts, variations in canal calcifications, and the applied configuration. Thus, further development is needed to improve the algorithm and validate the accuracy using external validation data sets.
Measure
Measure

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2023年4月8日
发表者 kimi1006
暂无评论

阿里轻量应用服务器开启HTTPS加密访问

轻量应用服务器
wordpress 6.0
nginx 1.22

查了很久google,没找到有用的信息,后来发现不需要怎么改配置文件,就能自己开启加密访问。
我是将我的wordpress.conf和nginx.conf两个文件的内容喂给chatgpt后,它告诉我的这个方法。

第一步:只要从阿里云-ssl证书-下载apache的证书文件(chain.crt,public.crt以及.key的三个文件),虽然服务器用的nginx,但是chatgpt告诉我apache的几个文件就可以用。

第二步:
将下载来的文件,重命名如下:

  1. public证书文件(.crt):改为www.example.com.crt
  2. 证书密钥文件(.key):改为www.example.com.key
  3. chain.crt文件:改为chain.crt。

将这三个文件放在/usr/local/nginx/conf/ssl/目录下。记得备份原来在文件夹里的三个文件。

第三步:
修改wordpress.conf文件,记得用命令修改或者通过filezilla等工具连接服务器后用visual studio code等工具编辑代码,编辑完传回去替换原文件。
我的wordpress.conf在这个路径/usr/local/nginx/conf/vhost
在ssl_certificate的下面一行,添加一行ssl_trusted_certificate /usr/local/nginx/conf/ssl/chain.crt;

第四步:
检查:sudo /usr/local/nginx/sbin/nginx -t
加载重启:sudo /usr/local/nginx/sbin/nginx -s reload

访问你的网站,应该已经自动开启HTTPS了。

点击数:0

2023年4月7日
发表者 kimi1006
暂无评论

小鼠bmsc成骨诱导后基因变化查询

GeneNamesvalue1(osteogenic)value2(normal medium)log2.Fold_change.log2.Fold_change..normalizedz.scorep.valueq.value.Benjamini.et.al..1995.q.value.Storey.et.al..2003.Signature.p.value…0.001.
1Mgp3202.32469.992.7684155141052.785869648686547.8577043815270001
2Postn2440.12298.9783.02884086410263.046294998684143.6565766606860001
3Gsn2984.37588.3892.34258423034522.360038364926742.1380294483410001
4Gas62095.56228.0463.1999390590573.217393193638541.4774091006820001
5Fth12742.07604.2312.18209329256042.19954742714238.7053187728590001
6Acta2365.1522051.57-2.490159342534-2.4727052079525-35.6722204520121.07E-2783.08E-2753.08E-2751
7Sepp11082.8826.5565.34969171148515.367145846066734.2596884454473.13E-2577.74E-2547.74E-2541
8Timp3150.2851376.46-3.1951897601081-3.1777356255266-33.2245298620434.76E-2421.03E-2381.03E-2381
9Mt21032.7436.80234.81053734854554.827991483127133.0440453717411.89E-2393.64E-2363.64E-2361
10Snord6501958.18-11.935297671244-11.917843536662-32.6757163801653.46E-2345.99E-2315.99E-2311
11Snord992257.76616.7981.87202214334841.889476277929931.8337918608042.21E-2223.47E-2193.47E-2191
12Cst31479.65243.4062.60381932133972.621273455921231.4840299764551.44E-2172.07E-2142.07E-2141
13Snord69481.0341971.21-2.0348707060462-2.0174165714647-30.8720869851612.83E-2093.77E-2063.77E-2061
14Ly6a1867.89470.8751.98799346398542.005447598566930.1169053365022.91E-1993.60E-1963.60E-1961
15Snord7001515.89-11.565949353334-11.548495218753-29.6999503709287.69E-1948.88E-1918.88E-1911
16Tagln245.4751369.91-2.4804331062695-2.462978971688-29.0794503410086.53E-1867.07E-1837.07E-1831
18Lox01276.64-11.318136041154-11.300681906573-27.8409873528331.38E-1701.33E-1671.33E-1671
19Scarna1710334.26856.350.591914047416130.6093681819976427.5278644472888.15E-1677.43E-1647.43E-1641
20Mt1855.99678.70013.44316668104323.460620815624727.3300967479711.86E-1641.61E-1611.61E-1611
21Ibsp728.84849.49823.88017000663213.897624141213626.3308934773328.50E-1537.01E-1507.01E-1501
22Rnu73b261.5181214.55-2.2154397292241-2.1979855946426-25.5829674356332.36E-1441.86E-1411.86E-1411
23Serpine1382.9961427.91-1.8985038204705-1.881049685889-25.0820027475857.82E-1395.89E-1365.89E-1361
24Tpm1444.031492.28-1.7487891994601-1.7313350648786-24.2215799488981.32E-1299.51E-1279.51E-1271
25S100a46617.764196.780.657060134267450.6745142688489624.0687509029695.31E-1283.68E-1253.68E-1251
26Hp482.5987.911765.93067946327465.948133597856122.9178735011873.08E-1162.05E-1132.05E-1131
27Ly6c1670.49288.31352.92451422194712.941968356528622.4964899233534.49E-1122.88E-1092.88E-1091
28Myl9179.486841.703-2.2294399419189-2.2119858073374-21.3789038560082.10E-1011.30E-981.30E-981
29Snora682661.261366.320.961814055109940.9792681896914520.9809086185979.80E-985.85E-955.85E-951
30Tsc22d3456.00734.4573.72618696700923.743641101590720.5447246740698.58E-944.95E-914.95E-911
31Mir65461181.052419.89-1.0348714261364-1.0174172915549-20.5223414121181.36E-937.60E-917.60E-911
32Glul387.15115.62094.63134688656564.648801021147120.0941790179758.30E-904.49E-874.49E-871
33Actb2538.664214.55-0.73131140923343-0.71385727465192-20.0463030516432.17E-891.14E-861.14E-861
34Mir62361526.23624.9631.28812970518131.305583839762820.0086254500224.63E-892.36E-862.36E-861
35Snord110481.0341314.14-1.4499082053251-1.4324540707436-19.8055219615552.67E-871.32E-841.32E-841
36Actg261.2003504.563-3.0434237861879-3.0259696516064-19.6624446793594.52E-862.18E-832.18E-831
37Serpina3n491.127010.01219844411910.02965257870119.2179830703682.62E-821.23E-791.23E-791
38Ctgf169.825727.052-2.0980096976605-2.080555563079-19.1191272980731.75E-817.98E-797.98E-791
39Snord472077.673513.71-0.75802859845582-0.74057446387431-18.895319662091.25E-795.53E-775.53E-771
40Snora613838.412419.890.665567352361380.6830214869428918.5119625863131.65E-767.16E-747.16E-741
41Mir18921229487.81.33312325246381.350577387045318.4274074896927.92E-763.34E-733.34E-731
42S100a101410.64611.4221.20610948547041.22356362005218.2851495025651.09E-744.48E-724.48E-721
43Mir30641097.862142.33-0.96448663448312-0.94703249990161-18.1927398794435.89E-742.37E-712.37E-711
44Lgals12010.333343.03-0.73372395926472-0.71626982468321-17.8999848161051.18E-714.64E-694.64E-691
45Snord223151.031951.450.691276991325890.708731125907417.3213430909643.25E-671.25E-641.25E-641
46Aldh1a1259.5367.952235.02843137299485.045885507576316.6699436675992.17E-628.16E-608.16E-601
47Mir3960393.50159.72262.72001842292752.73747255750916.6138907911955.53E-622.04E-592.04E-591
48Fabp4334.63936.5293.1954914270623.212945561643616.5595051248661.37E-614.93E-594.93E-591
49Anxa11924.421047.50.877473454242980.8949275888244916.5405326973481.87E-616.62E-596.62E-591
51Gm255000328.535-9.3599032639347-9.3424491293532-16.3932891704172.14E-607.25E-587.25E-581
52Mir512180.3314438.916-2.4499089375049-2.4324548029234-16.3387942687065.23E-601.74E-571.74E-571
53Ldha249.581749.907-1.587203580847-1.5697494462655-16.0066750633371.15E-573.75E-553.75E-551
54Dpep1237.4366.547735.18040004993025.197854184511815.9976842422951.33E-574.25E-554.25E-551
55Comp292.44727.2483.42395294435893.441407078940415.9373789390093.49E-571.10E-541.10E-541
56Crip1879.703340.921.36758329462791.385037429209415.8910184329237.31E-572.26E-542.26E-541
57Snord66290.91609.18445883473789.201912969319315.6631747365972.70E-558.20E-538.20E-531
58Itgbl1234.34112.19094.26473284558414.282186980165615.3448846205123.83E-531.14E-501.14E-501
59Actg1616.171288.92-1.0647623745884-1.0473082400069-15.3313349443394.72E-531.39E-501.39E-501
60Tpm4470.5531066.04-1.1798324390656-1.1623783044841-15.1678434005595.77E-521.67E-491.67E-491
61Tpm2152.024544.122-1.8396310611393-1.8221769265578-15.1486748189617.73E-522.19E-492.19E-491
62Gas1231.22412.97484.15550694534644.172961079927915.1375304323499.16E-522.56E-492.56E-491
63Snord2422.34896.15122.13505545114042.15250958572214.9783214946931.02E-502.80E-482.80E-481
64Timp1658.3961326.24-1.0103143971057-0.99286026252422-14.8833073716854.23E-501.14E-471.14E-471
65Cxcl12376.6775.59112.31701284548482.334466980066314.8644801938995.60E-501.49E-471.49E-471
66Ctla2a212.8179.021024.56017902174854.5776331563314.8518721817846.77E-501.78E-471.78E-471
67Col5a2496.3971084.29-1.1271843643159-1.1097302297344-14.7383159746143.66E-499.45E-479.45E-471
69Igfbp6432.495109.0431.9877862947512.005240429332514.485270660781.50E-473.77E-453.77E-451
70Cdkn1c195.1811.626496.90690685716566.924360991747114.325855149581.51E-463.73E-443.73E-441
71Figf179.1747.877624.50745766636774.524911800949213.5941131938234.34E-421.06E-391.06E-391
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73Efemp1253.4237.62122.75191261477692.769366749358413.4133180979885.05E-411.20E-381.20E-381
74Mir150197.87308.62843095818068.645885092762113.3648893337589.70E-412.27E-382.27E-381
75Mir30821346.26766.2220.813122706557780.8305768411392912.9808697305551.57E-383.63E-363.63E-361
77Scarna3a438.318144.1371.604537202711.621991337291512.6055906212731.97E-364.42E-344.42E-341
78Mir6942171.69808.42372942418248.441183558763912.5937122676122.29E-365.01E-344.95E-341
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80Mir7231171.69808.42372942418248.441183558763912.5937122676122.29E-365.01E-344.95E-341
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123Txnip203.08747.40722.0989198016862.116373936267510.2757017929679.07E-251.28E-221.28E-221
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984Ptgs2os21.0624710.7-3.3321167857573-3.3146626511758-2.98318149370790.00285268776875140.0502032460279140.050203246027914
985Slc7a221.24746.18921.77946146489951.7969155994812.98249610953410.00285908282136590.050264707835120.05026470783512
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993Lum10.35761.03233.32675554621763.34420968079912.96397795612020.00303690040874620.052960729484650.05296072948465
9943110062M04Rik21.38866.366881.74818357502591.76563770960742.95628315073860.00311371096680240.0542456064508220.054245606450822
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1003Oplah10.92761.295613.07627316683023.09372730141172.941352805910.00326782108106020.0564195988641260.056419598864126
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1007Scrn138.445517.19041.16121162734171.17866576192322.92916621079160.00339872628776270.0584466168075350.058446616807535
1008Fgfrl129.314711.22811.38451047460681.40196460918832.92687165537810.00342390143423120.0588211320799420.058821132079942
1009Phyhd115.833537.1186-1.2291620985436-1.2117079639621-2.92422119287430.00345319269937160.0592655480426340.059265548042634
1010Camk2d50.898825.9540.971674741259040.989128875840552.92283172966520.00346863913913280.059471706903330.05947170690333
1011Vegfc12.0441.794282.74683766558082.76429180016232.92122261488420.00348660597387720.0597206287335630.059720628733563
1012Irak315.93343.595532.1477778015772.16523193615852.91970169303110.00350366589108320.0599535397587820.059953539758782
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1014Carhsp184.092151.17620.716497246879980.733951381461492.91375440544460.00357110728493110.0609870462062640.060886827897944
1015Mak1630.110657.6968-0.93821984956933-0.92076571498782-2.91367527554910.00357201251360660.0609424046286950.060886827897944
1017Acadsb70.744940.83550.792802255275810.810256389857322.91160715038270.00359574555722130.0612266723838740.061226672383874
1018Gria334.762214.83271.2287381532481.24619228782952.91062794559970.00360703250566440.0613585283895780.061358528389578
1019Apoe10.65481.252883.08818336668253.1056375012642.90957630389590.00361919028881080.0615049246627450.061504924662745
1021Steap312.50282.032272.62108723121592.63854136579742.90353255449130.00368978607935210.0625818075770230.062537281631701
1022Mir706339.150617.82591.13505949983811.15251363441962.90344888094420.00369077217922260.0625372816317010.062537281631701
1023Sdc321.00844.6471-1.0876276484825-1.070173513901-2.90282141093970.00369817460533690.0626014561491880.062601456149188
1024Acot24.1427517.1599-2.0503804788777-2.0329263442962-2.89326977210870.00381253681293820.0644743163961430.064474316396143
1025Fbxl550.868526.16270.959261117765850.976715252347362.89150432647530.003834023136160.0647744181940320.064774418194032
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1028Selt50.793285.0788-0.74416431743489-0.72671018285338-2.88800441558020.00387694429962870.0653084089850890.065281521926515
1029Thsd7a16.38053.916842.06421729303112.08167142761262.88764795048090.00388134021151160.0653189197694320.065281521926515
1030Serpina3g7.8846504.81613033086674.83358446544822.8875225456930.00388288777411270.0652815219265150.065281521926515
1031Manf43.945876.0834-0.79185642819838-0.77440229361687-2.88633322274460.00389759254878340.0654651892990130.06542830829028
1032Tcp11l218.42194.990111.88427834272561.90173247730712.88620547384620.00389917503930060.065428308290280.06542830829028
1033Ech182.648750.330.715573529386310.733027663967812.88546417937690.00390836935498550.0655191017621330.065519101762133
1034Abce161.674999.0323-0.68321567456225-0.66576153998074-2.88484725497030.00391603611042310.0655841366771730.065584136677173
1035Lonp122.449646.535-1.0516264675436-1.0341723329621-2.8817879638950.00395425728897470.0661602642252890.066160264225289
1037Hist1h4k18.738441.0722-1.1321644541407-1.1147103195592-2.87775018712390.00400522172990250.0668837268049390.066883726804939
1038C226.4259.698731.44603572050041.46348985508192.87005605053210.00410399043666930.0684670543273630.068467054327363
1039Plin374.717244.29120.754420306293910.771874440875432.86951907128320.00411096540552810.0685174089774110.068517408977411
1041Trim30d11.18391.557322.84428603941912.86174017400062.86542074394830.0041645550617610.0692772334337320.069277233433732
1042Mirlet7e35.236964.1759-0.86494461587024-0.84749048128873-2.86452652835240.00417633171254960.0694064647468530.069393048974309
1043Cycs24.345849.0781-1.0114064896993-0.99395235511779-2.86428394624230.0041795316787090.0693930489743090.069393048974309
1045Zhx318.11024.91141.88259624868661.90005038326812.85998599386140.00423659718762450.0702058885149220.070205888514922
1047Prmt132.311860.1271-0.895954256004-0.87850012142249-2.85873873295660.00425328932344640.0703478617135830.070299992393906
1049Arrdc431.689213.0991.27453456089711.29198869547862.8583492277530.00425851429353850.0702999923939060.070299992393906
1050Gprc5b13.7552.714782.34104894471412.35850307929562.85759796384290.00426860847616590.070399517125490.07039951712549
10513300005D01Rik13.903133.5613-1.2713920005767-1.2539378659951-2.85649278636910.0042834973778950.0705778535613770.070577853561377
1054Fhl36.6331321.4982-1.6964541649329-1.6790000303514-2.84379375697820.00445798939963350.0732438353258560.073243835325856
1055Prps232.185813.51611.25174539890781.26919953348942.8410453377760.00449659192211750.0738080401092980.073808040109298
1056A4galt29.126911.54191.33547142588141.35292556046292.83945857373050.00451901623647580.0741058751581920.074037805342726
1057Pcolce228.810211.33991.34517175765551.3626258922372.83944978346820.00451914074304220.0740378053427260.074037805342726
1060Oxct192.730158.90730.654591281735380.672045416316892.83189977150340.004627235051840.0755941786723710.075594178672371
1063Lmod111.606729.7069-1.355840218117-1.3383860835355-2.82677819433970.00470188833276470.0765969898950960.07657907170592
1064Adipoq7.6451507.00952250068057.0269766352622.82655198465560.00470521061933930.076579071705920.07657907170592
1066D15Ertd621e30.137856.7082-0.91198325692421-0.8945291223427-2.81908376956140.00481609474729320.0782366911246490.078236691124649
1067Hist1h4a10.322327.5514-1.4163611641219-1.3989070295404-2.81570587056180.00486702027666160.078989868913730.07898986891373
1068Skil4.596717.5421-1.9321510480543-1.9146969134728-2.81221498432030.00492016062189430.0797775482109950.079777548210995
1069Ctsf40.542719.36671.06586402434561.08331815892722.8107298958740.0049429262133740.0800717055537860.080071705553786
1070Id233.044814.2591.212550456561.23000459114162.80882263050580.00497230327398690.0804723138276920.080459469128617
1071Slc31a227.853610.88261.35584052683721.37329466141882.80857326139840.00497615588362580.0804594691286170.080459469128617
1072Prelid22.7196613.7257-2.335381518993-2.3179273844115-2.80819962076770.00498193346958540.0804777443029940.080477744302994
1075Ddx3926.515651.5482-0.95908065690569-0.94162652232418-2.80627703395360.00501175835276080.0807335994369850.080733599436985
1076Glce24.538848.7585-0.99058904392159-0.97313490934008-2.8052497104870.00502776120581260.0809161159861130.080916115986113
1077Limk121.15826.821151.63313000415511.65058413873662.80407099000370.00504617930804030.081137128205510.08113712820551
1078Nutf2-ps161.992498.2785-0.6647844802062-0.64733034562469-2.80322511979460.00505943402617440.0812747857432850.081196579516852
1079Pi167.2195805.59448904913395.61194318371542.8032166147980.00505956745846240.0812016030381770.081196579516852
1080H2-K165.266237.61720.794943576336750.812397710918262.80293781112790.00506394328568460.0811965795168520.081196579516852
10812410002F23Rik13.653632.7149-1.2606664688254-1.2432123342439-2.80132116735640.00508938403238440.0815290132181310.081529013218131
1082Hist1h3c9.926426.7496-1.4301748217432-1.4127206871617-2.79512885582260.00518790325457170.0830304257480770.083030425748077
1083Sqrdl48.533325.20170.945453903732480.962908038313982.79109665669050.0052529782914020.0839942983122880.083994298312288
1085Ifrd125.604250.109-0.96868926395224-0.95123512937073-2.79040643849780.00526419124241620.0840184329446280.084018432944628
1086Sult5a17.2245206.40807355580296.42552769038442.78851079373610.00529509829140220.0844339015766220.084433901576622
1087Rpl39l20.706843.1034-1.0576970550112-1.0402429204297-2.78684202139930.00532244190687720.0847918367078120.084791836707812
1088Mir63657.9922903.99860893222584.01606306680732.78308031379650.00538454753166750.0857023985348230.085702398534823
1089Hist1h2bj19.32541.042-1.0866326218576-1.0691784872761-2.78104660272090.00541839583195760.0861619473113040.086161947311304
1090Map2k140.349670.0169-0.79514881619878-0.77769468161727-2.77905137806820.00545179014107560.0866134402504640.086613440250464
1091Islr28.1428408.20244795476928.21990208935072.77506669117160.00551903890679020.0876014635645160.087601463564516
1092Slc3a242.743473.075-0.77367625309386-0.75622211851235-2.77099925761490.00558845542294010.0886220536255070.088584915843438
1093Rtp415.40633.772232.03003087600392.04748501058552.77083768856450.00559122902447760.0885849158434380.088584915843438
1095Crebrf20.14776.388711.6570185958981.67447273047952.76442519441220.00570231803064530.0901799464261960.090179946426196
1096Bscl247.872924.93620.940967571730810.958421706312322.7612720291080.005757669724170.0909722323115430.090972232311543
1098Mir3473f47.696224.81940.942406090712070.959860225293582.75961995454240.00578686378968850.0912669583297220.091266958329722
1100Wsb255.058488.7488-0.68876492676142-0.67131079217991-2.75106594577010.00594016837136150.0935144506244240.093514450624424
1101Ids22.97148.126961.49905108634321.51650522092472.74751739891670.00600483227875270.094446576358910.09444657635891
1102Chd338.591267.2784-0.80187149072023-0.78441735613872-2.74450850887550.00606015834044270.095230274030350.09523027403035
1104Cks1b43.555473.7248-0.75929840826764-0.74184427368614-2.73718653813050.00619671442675480.0971997316377830.097199731637783
1105Egfr47.881525.12650.93025862401870.947712758600212.73573637878480.00622408660984570.0975407310612660.097540731061266
1106Gm1005250.773683.0528-0.70995025221222-0.69249611763072-2.73523779420630.00623352265696640.0976002819626470.097600281962647
1108Dhrs912.35482.380852.37552302156232.39297715614382.73146852885530.00630527626357210.0985455496897830.098545549689783
1111Fam105a17.83475.223671.77155128413771.78900541871922.72419846712050.00644577592765840.100469398505190.10046939850519
1112Tspan521.47667.33861.5491888472041.56664298178552.72070909353510.00651420598191340.101444698730930.10144469873093
1114Scn1b63.909137.32870.775736104189630.793190238771142.71709397652120.00658579050215070.102375344816650.10237534481665
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1116Mir648107.78092-3.9599407465954-3.9424866120139-2.71384703502280.0066506867733910.103152658177170.10301426015636
1117Mir69807.78092-3.9599407465954-3.9424866120139-2.71384703502280.0066506867733910.103152658177170.10301426015636
1118Mir70807.78092-3.9599407465954-3.9424866120139-2.71384703502280.0066506867733910.103152658177170.10301426015636
1119Tasp129.967212.73421.23467596312971.25213009771122.71251992424880.00667737670297180.103335238932410.10327032946894
1120Tcea140.548469.4824-0.77700259897553-0.75954846439402-2.71234247532360.00668095272125920.103298266316110.10327032946894
1121Fam150a2.1850812.0321-2.4611304569045-2.443676322323-2.7121363205990.00668510939161960.103270329468940.10327032946894
1122Samd9l41.917221.01650.996019921532211.01347405611372.70627675008990.00680423152282040.105016824670840.10489882359026
1123Myof101.83267.72670.588394382660650.605848517242162.70619468264290.00680591337253240.104949244765930.10489882359026
1125Deptor6.9736404.71487818688214.73233232146362.70576336588840.00681475870757290.104898823590260.10489882359026
1126Peak133.196314.94511.15134989998731.16880403456882.70369996616290.00685721747083750.105458645597240.10545864559724
1131Hist1h3e25.133648.4768-0.9476771384717-0.93022300389019-2.69374740727430.00706536867986820.108179477833140.10817947783314
1132Bud3147.690978.497-0.71892350926403-0.70146937468252-2.6894264069490.0071574926966110.109493198787290.10949319878729
1133Rab3d12.49852.564192.2851798900072.30263402458852.68529935455250.00724648698233110.110756765289520.11075676528952
1134P3h138.101665.8957-0.79033274369824-0.77287860911673-2.68156027683160.00732797114945270.111903418337810.11190341833781
1135Hk27.729222.257-1.5258681434185-1.508414008837-2.67755478853780.00741617223460980.113150532675540.11307430672588
1136Eno34.8302217.1512-1.8281487139636-1.8106945793821-2.67748552038260.00741770586363690.113074306725880.11307430672588
1137Yars21.684643.4253-1.0018649846031-0.98441085002154-2.67283158810080.00752139997739050.114554163068140.11455416306814
1139Rnf12515.25353.994391.93309320992771.95054734450922.67102380397130.00756202839704980.114970716199920.11497071619992
11405430416N02Rik6.3853419.9018-1.6400635736725-1.622609439091-2.67023926464760.00757972139747930.115138627579080.11513862757908
1141Siglecg4.19115.8812-1.9219535015572-1.9044993669757-2.66622888236870.00767074492887270.116419184867040.11641918486704
1142Hdac241.419270.0291-0.75765485778297-0.74020072320146-2.66254313438950.00775526292318930.117598851174140.11759885117414
1145Tnfaip261.219435.75640.7757874138930.793241548474512.65944854191810.00782686851377060.118373696116130.11837369611613
1146Olfml2b69.919142.53160.717151485703570.734605620285082.65893901952230.00783871494593980.118449412494620.11844941249462
1147Socs243.839222.7280.94775073486630.965204869447812.65795310125910.00786168323708340.118692910738080.1185131749341
1148Pdk14.6792916.7506-1.8398512253574-1.8223970907759-2.65773766423560.00786671015095980.118665348156940.1185131749341
1149Ier3ip137.12464.3268-0.79306775726681-0.7756136226853-2.65755963578120.0078708663621010.11862471087250.1185131749341
1150Hnrnpa2b161.904596.1176-0.63475633914297-0.61730220456146-2.65742896593290.00787391820175030.118567514347570.1185131749341
1152Gm1223819.813540.5965-1.0348716009574-1.0174174663759-2.65572274863720.00791386489237010.118962151337820.11896215133782
1153Eno126.490749.9679-0.91551562071472-0.89806148613321-2.65506516868720.00792930883049850.119090928896570.11902064186643
1155Ptbp141.387569.8937-0.75596731581003-0.73851318122852-2.65467967516710.00793837508550690.119020641866430.11902064186643
1156Mir218-207.47834-3.9027180642909-3.8852639297094-2.64806852365470.0080953114570110.121268605969770.12126860596977
1158Gstt113.86673.344022.05196911459352.0694232491752.6468288257180.00812504690351450.121503831803250.12150383180325
1159Emilin259.895934.85670.781021259712750.798475394294262.64549865644590.00815706109546480.121877331311620.12187733131162
1161Wwp120.97037.360161.51053846671121.52799260129272.63974259216830.00829690184341770.123753186238130.12372856011317
1162Ssh211.75342.324572.33804238145792.35549651603942.63951823223920.00830239572971650.123728560113170.12372856011317
1163Abhd11os17.30365.22191.72842548537921.74587961996072.63828809856530.00833257581217650.124071552312520.12407155231252
1164Tnfrsf1a75.007746.76840.681504631328860.698958765910372.63660148351760.00837411472762440.124582942215010.12458294221501
1165Nudt2230.16413.27381.18424631276061.20170044734212.63473177223520.0084203794405350.125163700233260.12515877039411
1166Mir11937.3087803.86963060797793.88708474255942.63416283054830.00843450280359920.125212417531010.12515877039411
1167Mir466i7.3087803.86963060797793.88708474255942.63416283054830.00843450280359920.125212417531010.12515877039411
1168Arrb115.76784.397361.84227183030511.85972596488662.63030510164220.00853082689140450.126479733971280.12647973397128
1169Ifi27l2a7.8461103.47770123505113.49515536963262.62654940152290.00862554708435880.127774678237670.12777467823767
1170Gm1400512.618429.6623-1.2331014783001-1.2156473437186-2.62076972620730.00877314988245040.129850116678970.12985011667897
1171Rsl1d153.747185.3411-0.66705379203506-0.64959965745355-2.62032069637860.00878471125297410.129910200484850.12991020048485
1172Mcam1.5559310.1123-2.7002621082239-2.6828079736423-2.61887612282990.00882199772864240.130350285551960.13032260117179
1174Chrd10.79231.942362.47411983543322.49157397001472.61306510368760.00897342069009210.132361776908280.13236177690828
1176Map3k613.10653.057662.0997825766732.11723671125452.61098465507880.00902819446607510.13294323432740.1329432343274
1177Nucb283.161853.57330.634406819318950.651860953900462.61037649162120.00904426240474180.133066688243770.13306668824377
1178Wsb134.309760.0149-0.80670421431772-0.78925007973621-2.60590590027370.00916316316546880.134701609963010.13468029702644
1181Snx2124.63419.794971.33054378521951.3479979198012.60400766741470.00921406954505110.135105878333320.13510587833332
1183Kansl213.199230.4094-1.2040668603362-1.1866127257546-2.60325677860740.00923427628052440.135173256424210.13515444722477
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1187Stat217.01845.191731.71280814523221.73026227981382.6000774824090.00932027137708850.135972316290680.13586682844483
1188Maoa50.183727.83660.850235834080920.867689968662432.6000548339170.00932088653880340.135866828444830.13586682844483
1189Fap15.30654.253171.84753400640021.86498814098172.59650740188730.00941768765525960.137162402965630.13716240296563
1190Cdc42ep233.770615.95561.08170495059021.09915908517172.59563379927570.00944166341101280.137396038057570.13739603805757
1191Rab3il112.97783.036172.09572136110562.11317549568712.59497552870670.0094597653968540.137543876891120.13754387689112
1192Golt1b39.6566.9137-0.75498075448268-0.73752661990117-2.59444095974110.00947448844297880.137642379502570.13764237950257
1193Adcy58.3397903.13983363379823.15728776837972.59364656185760.00949640542409780.137845140594380.13784514059438
1194Meox213.3153.214622.05033231668112.06778645126262.5923244811670.00953298112690180.138260162625260.13826016262526
1195Lpar155.447531.89130.797959506016010.815413640597522.59173642298490.00954929023433110.138380802500350.13836470299228
1196Atp6v1b249.022227.030.858873718514720.876327853096232.59148865062240.00955616935836250.138364702992280.13836470299228
1197Glmp60.498235.8280.755804707294520.773258841876032.58607740205940.0097075128387850.140438596348570.14043859634857
1198Net138.7919.56680.987276942317331.00473107689882.58482197940.00974292876259960.140833303323820.14083330332382
1199Nrp220.293140.6231-1.0013110678376-0.9838569332561-2.58394635922520.00976769844615360.141073589651410.14107358965141
1201Vimp55.588587.1377-0.6485105808825-0.63105644630099-2.5804577377930.00986694326785160.142269655761350.14226965576135
1202Zbtb3820.571340.9706-0.99395605310826-0.97650191852675-2.57886061980750.00991267738356610.14281017824560.1427766223984
1203Mir1b7.0633503.82035258606073.83780672064222.57865451195980.00991859310188140.14277662239840.1427766223984
1204Alyref58.946891.3201-0.63151894254073-0.61406480795922-2.57811644302710.00993405161032230.142880375195970.14288037519597
1205Kctd520.915541.4466-0.98668127053578-0.96922713595427-2.57772275721930.00994537564127410.142924539402440.14292453940244
1206Ccnd344.295923.62570.906816094815070.924270229396582.57666555534540.00997584205860090.143243496624210.14324349662421
1209Pvr6.2052818.9293-1.6090528461178-1.5915987115363-2.56817458915050.0102235650333480.146436290887090.14643629088709
1210Mir3471-17.0077503.80895130801653.8264054425982.56591941248590.0102902732592410.147269968620070.14726996862007
1211Nes07.88555-3.3439807750201-3.3265266404386-2.56485246335820.0103219684506590.147601591791960.14759030632823
1212Col28a18.1774703.12984657844783.14730071302932.56459256957720.0103297021002380.147590306328230.14759030632823
1213Hbp164.861239.43590.717846147391420.735300281972932.56306860040160.0103751546565010.148117521176110.14811752117611
1214Pkp21.600839.94208-2.6347276030093-2.6172734684277-2.56224168659750.0103998918662130.148348375162450.14834837516245
1215Arl4a11.95562.617862.19122668364272.20868081822422.56051991399540.0104515673337870.148962791373820.14896279137382
1216Ablim37.5051503.44374381604943.46119795063092.5589013896090.0105003521969380.149535032067740.14953503206774
1218Ywhag60.694493.215-0.61899871798216-0.60154458340065-2.55716368475750.0105529547462630.150037370559150.15003737055915
1219Atp1b114.5473.979231.87016046505691.88761459963842.55195299549050.0107120969499050.152175047482780.1521368835803
1221Rcc222.260743.0857-0.95271016335395-0.93525602877245-2.55105732713140.0107396658890830.152316784767610.15231678476761
1223Foxred29.669881.581582.61213145387052.6295855884522.54877047563660.0108103422141030.153068435095350.15304362647467
1224Nfe2l241.241368.4424-0.73080054046641-0.7133464058849-2.54854194023770.0108174278919560.153043626474670.15304362647467
1225Atp2a252.139282.3456-0.65932311701273-0.64186898243122-2.54669774881260.0108747577859440.153729127003420.15372912700342
1226Dok145.014973.2676-0.70277274388394-0.68531860930243-2.54558446657360.0109094966674250.15409441581550.1540944158155
1227Srsf237.863163.9849-0.75693894413055-0.73948480954904-2.54289641023030.0109937816960970.155158368077680.15515836807768
1228Klhdc8a32.926915.69411.06904439361431.08649852819582.53904695322170.0111154904409630.156748328962660.15674832896266
1229Il1r25.9147105.78848990777875.80594404236022.53820633516510.0111422270457220.15699751485010.1569975148501
1231Gjb521.46328.091861.40732192232561.42477605690712.53512774049370.0112406328175830.158126757515910.15812675751591
1232Fam107a5.9737506.432734592596.45018872717152.5345392091640.0112595325641910.158264062836110.15826406283611
1233Smarcd237.483918.95260.983875288389691.00132942297122.53382178123970.0112826097813590.158459816369660.15845981636966
1235Plin260.606992.7524-0.61390256083867-0.59644842625716-2.53143481195720.0113596930806380.159284052694260.15928405269426
1236Nedd922.793143.6288-0.93668364003517-0.91922950545366-2.53011326640190.011402571027210.15975592433510.15966308658774
1237Mme11.0322.246222.29612322129262.31357735587422.53003346635020.0114051647576970.159663086587740.15966308658774
1238Lrrc1727.314949.823-0.86712375208263-0.84966961750112-2.52947598810410.0114232990130270.159787777874470.15973587656672
1240Tmod364.38339.38790.708927301951190.72638143653272.52653028492570.0115195455992890.160874170276520.16075054615868
1241Dhrs159.12735.27140.745318238487520.762772373069032.52651715533330.0115199761958150.160750546158680.16075054615868
1242Sparcl15.8574105.9051286383035.92258277288452.52506959768480.0115675378123940.161284261108880.16128426110888
1243Rnasel10.34071.950882.40613690568712.42359104026862.51750274645020.0118190048086480.164657848971320.16465784897132
1245Pnp56.468133.30740.761593348742350.779047483323862.51463251594430.011915651303240.165737617364030.16573761736403
1246Spry111.276126.7716-1.2474351866217-1.2299810520401-2.51290024787970.0119743187761970.166419966490690.16641996649069
1247Cdh251.988529.8820.798915819582380.816369954163892.51211746114250.0120009136558650.16665583141830.1666558314183
1248Acadm51.886129.80710.799692081197560.817146215779072.51169056345870.0120154393947650.16672384935830.1667238493583
1250Has2os6.782419.5422-1.5267251139443-1.5092709793628-2.50999915024120.0120731452135490.167256524530420.16725652453042
1251Pafah1b310.706225.8594-1.2722422928936-1.2547881583121-2.50872007012650.0121169464751230.167729146370670.16772914637067
1252Aldh1a77.4901603.28808558355963.30553971814112.50812876501210.0121372428917010.167875906673790.16787590667379
1254Pde4b1.9453510.4305-2.4227066691347-2.4052525345532-2.50208404834430.0123464610476850.170497341278120.17029787479249
1255Fyn17.467435.8626-1.0378152049037-1.0203610703222-2.50202534173030.012348508553130.17038973913510.17029787479249
1256Mical223.776444.7192-0.91136408721633-0.89390995263483-2.50193428023430.0123516850920690.170297874792490.17029787479249
1257Mir63856.7136703.74710162534883.76455575993032.49753221793180.012506110030390.172289822908720.17228982290872
1258Khdrbs310.645425.6757-1.2701734495129-1.2527193149314-2.49656663221580.0125402106587750.172622279791740.17262227979174
1259Lamb275.235648.33470.638356190987390.655810325568892.49618892895830.0125535720129210.172668948806790.17266894880679
1260Gng1255.805232.95060.760094824872510.777548959454022.49566765432560.0125720329449520.17278563056170.1727856305617
1261Ncs122.292442.6029-0.93439969322137-0.91694555863986-2.49496364807390.0125970034640290.172991521797450.17299152179745
1262Eva1c11.95652.801272.09364218520562.11109631978712.48922184435390.0128023053178770.175671569880890.17567156988089
1263Lif1.285658.84248-2.7819531080002-2.7644989734186-2.48803148024330.0128452362303310.176121105146990.17612110514699
1264Zfp52117.54135.893571.57354196191921.59099609650072.48654311278630.0128990939210140.176719627713770.17671962771377
1266Peli213.52833.633851.89640978446091.91386391904242.4838747530080.0129961508507010.177768044456230.17776804445623
1268Lims232.306215.60471.0498304425831.06728457716452.47876450189850.0131838320048920.180050803492680.17996976108347
1270Msn50.889279.89-0.65065541755969-0.63320128297818-2.47828191650770.0132016788710770.180010608669630.18001060866963
1271Taf957.232787.8224-0.61774929197483-0.60029515739332-2.47746946322470.0132317730943710.180279004465170.18027900446517
1273Ephx219.68097.235851.44356178992771.46101592450922.47375004853590.0133703203363870.181880469179270.18188046917927
1274Crispld15.6214805.95047035434775.96792448892922.47312314665450.013393798117030.182056830449460.18205683044946
1276Rab2936.435718.60170.969918233380640.987372367962152.46928636110070.0135382830903990.183732326235450.18362266789302
1277Srsf715.881633.2963-1.0680056040811-1.0505514694995-2.46921967313620.0135408065426690.183622667893020.18362266789302
1278Ivns1abp17.778436.0204-1.0186887101991-1.0012345756176-2.46868977874820.0135608723593830.183750881570760.18365873577416
1281Dpp725.68611.12551.20711206652011.22456620110162.46776999028430.0135957649030720.183792241082360.18379224108236
1282Adgrd117.65976.034681.54911165837031.56656579295182.46703261772480.0136237946808670.184027498041020.18402749804102
1284Tmed752.725381.9977-0.63708804453995-0.61963390995844-2.46274948844360.0137876211474840.185950339105120.18595033910512
1287Prc113.124129.1625-1.1518959104826-1.1344417759011-2.45937532968010.0139179027489040.187269869388320.18726986938832
1288Mir2206.64285-3.7318023377646-3.7143482031831-2.45769842473410.0139830540666260.188000424900440.18800042490044
1290Nrp159.700436.31750.717075702994550.734529837576062.45673385223340.0140206515932090.188213661736130.18821366173613
1291Hmgcr13.42229.5765-1.1398516758248-1.1223975412433-2.45559548046080.0140651383140130.188664601226770.18866460122677
1292Pdgfrb54.775584.4613-0.62475970434908-0.60730556976757-2.45498420577940.0140890778432920.188839443507970.18883944350797
1293Gbp312.51253.188271.9725243542041.98997848878552.45125841189920.014235771244410.190658043804680.19065804380468
1294Igf26.7137703.55466884520113.57212297978262.45024234520120.0142760093492130.191049191576760.19104919157676
1296Sox49.1988223.0595-1.3258405182243-1.3083863836428-2.44736854551460.0143903608080380.192282313358630.19228231335863
1298Foxo322.06248.859131.31635280648991.33380694107142.44439648040590.0145094713707810.193575127679360.19357512767936
1299Srpx34.903217.65850.982996513298941.00045064788052.44326571115810.01455501665690.194033274401490.19403327440149
1300Clmp37.594519.61430.938615764872040.956069899453552.44193860232920.0146086308808960.19459820074190.1945982007419
1303Dhrs356.128185.9372-0.61455954882698-0.59710541424547-2.43905807509310.0147256015152240.195704713307080.19570471330708
1306Epha26.2440918.1435-1.538889550987-1.5214354164055-2.43286501507920.0149798842556040.198626842001760.19862684200176
1307Mir316.4377403.68655431209283.70400844667432.4317150639850.0150275239435260.199106068959480.19910606895948
1309Appl220.44967.943831.36416596965191.38162010423342.41760176035460.0156231649113750.206681701123210.20668170112321
1310Edem227.254112.44171.13128965474631.14874378932792.41612739523130.0156865719353370.207362111606290.20736211160629
1311Sema3e8.328181.273492.70921361948522.72666775406672.41175858779310.0158757894938850.209703315534410.20970331553441
1312Lhfpl210.965125.5306-1.219308473998-1.2018543394165-2.40956477585860.0159715605641790.210807556623390.21072053309777
1313Thyn123.161742.9964-0.89247472424236-0.87502058966085-2.40929928230080.015983185098430.210800317097880.21072053309777
1314Idh275.91249.7560.609457453152270.626911587733782.40892977748510.0159993761066310.210853269435710.21072053309777
1315Cks227.677349.0936-0.82683175162063-0.80937761703912-2.40858198230890.0160146290113680.210893787520810.21072053309777
1316Car605.39272-5.914016878889-5.8965627443075-2.40848164145580.0160190319351950.210791471141160.21072053309777
1317Ugt1a6b13.41343.792711.8223740059311.83982814051252.4083272322170.0160258094409980.210720533097770.21072053309777
1318St3gal55.3602616.4624-1.6187997913575-1.601345656776-2.40558928029020.0161464060985610.212145155090130.21214515509013
1319Dnaja252.559381.0215-0.62435873319963-0.60690459861812-2.40304914618240.0162590021502360.213462577889040.21346257788904
1320Bzw241.822267.4696-0.68996865377038-0.67251451918887-2.40246643454760.016284928988440.213640996433950.21364099643395
1322Lamc146.375626.45260.80995641682580.827410551407312.40012131099030.016389639234790.214689396844820.2145806461326
1323Rgs167.1311819.4149-1.4449515513796-1.4274974167981-2.40002999594070.0163937284075430.21458064613260.2145806461326
1324Hist2h2ac28.200649.6916-0.81727613746115-0.79982200287964-2.39856729165730.0164593519381990.215276886339730.21527688633973
1326Rarres113.79944.042761.77119307464931.78864720923082.39593714383010.0165779329356010.216500802900310.21650080290031
1327Ube2l622.61019.435441.26080567159281.27825980617432.39443559231390.0166459667206080.217225475283170.21722547528317
1328Car5b16.79175.782741.53792315370241.5553772882842.39309305586960.0167070031662670.217857811619160.21782747466623
1329Cox6b211.34182.737892.05051323149742.06796736607892.39267615147960.0167259970540760.217941377716650.21782747466623
1331Srsf132.444855.2145-0.76705991322388-0.74960577864237-2.3903245019950.0168334921360780.219012459294110.21901245929411
1334Srprb19.177537.2982-0.95969134682767-0.94223721224616-2.38836630371020.0169234646083250.219687883525010.21968788352501
1335Tbx1558.224735.77620.702631142610810.720085277192322.38442932027610.0171056335493810.221886334213210.22182914409772
1336Arl14ep18.944236.9337-0.9631815811124-0.94572744653089-2.3840283365310.0171242837334630.221961992075130.22182914409772
1337Nfix25.715111.55551.15403607824341.1714902128252.38397330999160.0171268444683640.221829144097720.22182914409772
1338Agfg116.862833.9858-1.0110879732938-0.99363383871224-2.38288579330130.0171775225131140.222319250642450.22231925064245
1340Cdc42ep528.260513.33991.08303913915951.1004932737412.37678277974780.0174643692980170.225694390398330.22569439039833
1341Maob11.21692.716292.04596459553222.06341873011372.3761034591090.0174965562458930.225941733415460.22594173341546
1342Hist1h2ai9.703223.3406-1.2663091332887-1.2488549987071-2.37457962265920.0175689465082620.226707486351390.22670748635139
1343Eif4e27.494548.4806-0.81826450306565-0.80081036848414-2.37168032577040.0177074036548440.228323982941880.22821676977414
1344Hsd3b725.844911.70511.14274236031141.16019649489292.37157883568120.0177122676316020.228216769774140.22821676977414
1345Porcn26.802112.3631.11631717380151.1337713083832.37092243682720.0177437542471950.228452484980430.22845248498043
1346Slc35b149.128276.3142-0.63540014701101-0.6179460124295-2.37008216566670.0177841325609640.228802246328540.22870128428749
1347Maff7.4563319.752-1.4054611247144-1.3880069901329-2.36997076528530.01778949182510.228701284287490.22870128428749
1348Abcg241.885823.27320.847791637686810.865245772268322.36969244289950.0178028875798790.228703712329950.22870371232995
1350Pakap13.709929.297-1.0955348927299-1.0780807581484-2.36556451577220.0180026063570660.230926766137260.23092676613726
1351Snrpf38.205162.4033-0.70785708691985-0.69040295233834-2.36461678151840.0180487360144850.231347121808170.23124550886123
1352Hsd17b1241.821567.0244-0.68044159171842-0.66298745713691-2.36450543860460.0180541622671590.231245508861230.23124550886123
1353Ly753.7957713.4102-1.8208662719925-1.803412137411-2.3609940135140.0182260248310850.233274258684330.23327425868433
1355Zcchc58.030621.245182.68915706495932.70661119954082.35904571187190.0183219986863360.234156495388390.23409227360023
1356Fads349.822877.0435-0.62886714257082-0.61141300798931-2.35887373350020.0183304915979620.234092273600230.23409227360023
1358Nmrk16.7950518.5919-1.4521181421479-1.4346640075664-2.35747114956430.0183998850055990.234632406952840.2346043062237
13601110012L19Rik46.941727.22130.786134123332630.803588257914142.35490467651630.0185274577870030.235911754777590.23580910003459
1361Tapbp34.338817.78870.948878541798210.966332676379722.35466558905040.0185393815297130.235890132218980.23580910003459
1362Rassf220.40688.179121.31903243483761.33648656941912.35452031005620.018546630146510.235809100034590.23580910003459
1363Hyou123.902443.4735-0.86298076588624-0.84552663130473-2.35296694698990.0186242895116250.236622759701250.23662275970125
1364Snrnp7047.628874.1571-0.63875062610318-0.62129649152167-2.34764750527520.0188923909977840.239853031457940.23985303145794
1365Mars24.02243.5705-0.85899539869196-0.84154126411045-2.34610733065710.0189706437000710.240670063702660.24067006370266
1366Tmtc45.9002217.025-1.5288141442449-1.5113600096634-2.34516577766870.0190186212896860.241102097271960.24110209727196
1368Fgd32.4123410.634-2.1401792085422-2.1227250739607-2.34149464556330.0192067014578050.243130445281290.24313044528129
1369Cmtm729.302950.5377-0.78631655796634-0.76886242338483-2.33777994584550.0193986664467530.245381086090880.24536764107826
1371Plekho113.650728.9877-1.0864659351392-1.0690118005577-2.33691963265180.019443363307420.245587689565720.24558768956572
1374Pcdh98.417431.461722.52571283645452.5431669710362.33453860583580.0195675370270010.246616476489510.24661647648951
1376Pparg22.94949.933991.20801123602171.22546537060322.33395666934090.0195979909256310.246641285508110.24664128550811
1377Mthfd1l8.9089621.8163-1.2920775126196-1.2746233780381-2.33266093526610.0196659480268380.247316791561910.24731679156191
1378Tmem646.3762817.7327-1.4756253307212-1.4581711961397-2.33056387388280.0197763682789550.248524941572320.24852494157232
1379Jade29.403121.92752.28640866916952.3038628037512.32990729025180.0198110516332230.248780261880.24878026188
1381Smim118.78927.278711.36814895100591.38560308558742.32245175348590.0202086234166560.253405308983510.25340530898351
1382Calhm224.734211.19581.1435496177181.16100375229952.32134781717980.0202680794494750.253966955011980.25396695501198
1383Mir624463.096340.22040.64962797768910.66708211227062.32069534824360.0203032919681040.254224227774150.25422422777415
1389Arhgdib79.823353.97360.56455600575540.582010140336912.31120340559330.0208216223520740.259588217617610.25942986240022
1391Wars26.82546.9883-0.80872340212145-0.79126926753994-2.3108908770980.0208388830974590.259429862400220.25942986240022
1393Ndrg116.47415.888751.4841663192061.50162045378752.30984654397070.0208966514366150.259775529740020.25961172190211
1394Zwint45.873271.4941-0.64017263967879-0.62271850509728-2.30981377635840.0208984662661860.259611721902110.25961172190211
1395Adamts62.2270510.0991-2.1810208763926-2.1635667418111-2.30934600212480.0209243888571620.259747413505010.25974741350501
1396Iah163.274240.46910.644796596908940.662250731490452.30906585421460.0209399271948110.259754096871450.25975344566495
1397Abcc529.537514.60441.01614463578931.03359877037092.30879653125630.0209548746084160.259753445664950.25975344566495
1398Hspb212.31633.482921.82219967321851.83965380782.30758664835070.0210221378274930.26040083029950.2604008302995
1400Pfdn428.851949.6262-0.78243565957504-0.76498152499354-2.30645841726630.021085031066270.260806773553280.26070462846874
1401Mir19665.9300603.56804670194913.58550083653062.30606710938380.0211068827806880.260797637611970.26070462846874
1402Mir63875.9300603.56804670194913.58550083653062.30606710938380.0211068827806880.260797637611970.26070462846874
1403Capn132.815516.99890.948936022696120.966390157277632.30195824652490.0213375269339210.263365612198650.2633085784543
1405Six127.989413.55121.04645994836821.06391408294972.30127438479610.0213761266779540.263466466677680.26346646667768
1406Wdr7521.92440.2899-0.8779071849059-0.86045305032439-2.29920444362060.0214933328103880.264722648846010.26472264884601
1407Ptgfr12.40893.563831.7998748070051.81732894158652.29700587933510.0216184343434180.266074219989310.2660349314659
1408Fkbp1147.541673.425-0.62708090293191-0.6096267683504-2.29679258423070.0216306048105320.26603493146590.2660349314659
1409Ece163.371140.67360.639732369482740.657186504064242.29517582178250.021723050221830.266982299993910.26693144719074
1410Iigp17.812221.27052.6203362021542.63779033673552.29478885772190.0217452275059250.267065322496520.26693144719074
1411Dmkn4.9800106.80630648330516.82376061788662.29471013819290.0217497414093740.266931447190740.26693144719074
1412Ch25h1.140997.63328-2.742016965045-2.7245628304635-2.29408874670760.0217854016232310.26717974497840.26703379818721
1413Cyp20a142.140366.6066-0.66046455514427-0.64301042056276-2.29402745641370.0217889216861190.267033798187210.26703379818721
1415Hmga226.615812.63221.07517701244231.09263114702382.29322648136960.021834969312440.26721990359260.2672199035926
1416Mirlet7d29.261449.9622-0.77183820865656-0.75438407407505-2.28638883487450.022231520935510.271880824887160.27188082488716
1418Ccdc28b15.89245.626881.49792990894191.51538404352342.28403971978480.0223691967085610.273178687871750.27317868787175
1419Chsy124.79144.0131-0.82811652257678-0.81066238799527-2.28365880815550.022391590692460.27325946160770.2732594616077
1420Scp269.010345.36380.605270208729890.622724343311392.28312271693010.0224231407796870.273451780902710.27340730413311
1421Khk9.162561.91522.25825568321062.27570981779212.28291659029340.0224352820449930.273407304133110.27340730413311
1422Naga35.803919.33180.889140769691430.906594904272942.27921106987710.0226545213707410.275884913204730.27585516741996
1423Hist1h2an6.6792717.9123-1.4231882567393-1.4057341221578-2.27871641148350.0226839285322940.276048904001230.27585516741996
1424Eif2s145.519670.674-0.6346916846954-0.61723755011389-2.27847686238710.0226981815083590.276028377233320.27585516741996
1425Prodh5.405203.94049985098693.95795398556842.27844852681590.0226998679663590.275855167419960.27585516741996
1427Wdr4318.840735.8319-0.92739197775128-0.90993784316977-2.27339019806910.0230026763026410.279143199392320.27914319939232
1428Rnf14920.924338.6832-0.88652778440428-0.86907364982277-2.27206647061020.0230824958779670.279915673052350.27991567305235
1429Slc4a76.0776416.8808-1.4738001499969-1.4563460154154-2.27176490330850.023100713719770.279940559471840.27994055947184
1430Rilpl126.565612.71551.06297110438761.08042523896912.27026597897070.0231914499284720.280843593294650.28084359329465
1431Tgfa4.7294605.96400011630465.98145425088612.26825255195150.0233138180725270.282128153432530.28212815343253
1434Il4ra25.79245.1795-0.80874465558355-0.79129052100204-2.26602671838720.0234497474135410.283179411408850.28310498026704
1435Susd26.0176203.35031323046473.36776736504622.26586039384890.02345993224480.283104980267040.28310498026704
1436Cdc2014.092929.0685-1.0444881108865-1.027033976305-2.26469514246730.0235313937787760.283769600325260.28376960032526
1437Slmo237.431460.2917-0.68771039997147-0.67025626538996-2.2643308065780.0235537761887020.283841852651180.28384185265118
1438Rhou23.259610.47051.15149594947391.16895008405542.26337483696950.0236125925533990.284352757473720.28435275747372
1439Agmo9.047921.9072.24628132969632.26373546427792.26134043052920.0237381844464120.285666532354770.28566653235477
1440Sox1105.70186-3.6596735825804-3.6422194479989-2.26084774427180.0237686869275680.28583496633660.28567251868279
1441Rnf445.382770.291-0.63119753635896-0.61374340177745-2.26079950621810.0237716751990470.285672518682790.28567251868279
1442Mir16686.1768816.969-1.4579513395056-1.4404972049241-2.25910082338980.0238771139463860.286740625665440.28642480392202
1443Serpinb1a22.03979.667351.1889122068361.20636634141752.25904746423830.023880432556830.286581739838270.28642480392202
1444Ajuba7.6155319.2951-1.3412181717526-1.323764037171-2.25899179265370.0238838954127960.286424803922020.28642480392202
1447Tns217.80546.91671.36415905787711.38161319245872.25588097830370.0240780861002780.288154953005190.28815495300519
1448Pxdn14.514229.6007-1.0281662381769-1.0107121035954-2.25538424110750.0241092210371360.288328301588450.28820609725223
1450Pi1511.6053.240581.84042256734961.85787670193112.2550165726820.0241322885612830.288206097252230.28820609725223
1451Thbs46.6723602.95372497459632.97117910917782.25472516957260.0241505847890040.288225828250290.28822582825029
1454Ipmk16.49946.122831.43014302945831.44759716403982.24941511144390.0244860980673790.291627070311420.29162707031142
1455Lnx19.745372.280042.09565782635372.11311196093522.24865718593290.0245343150866570.292000504711780.29200050471178
1456Pcx14.57534.962511.55438366382751.5718377984092.24674552797490.0246562948009580.293250726008370.29325072600837
1457Rhbdd110.458223.5895-1.1735102744232-1.1560561398417-2.24564431021430.0247267998937950.29388743566290.2938874356629
1458Rnf748.552974.0332-0.60861492029885-0.59116078571734-2.24359548959930.0248584397330450.295249383303940.29498218119429
1459C430002N11Rik1.745758.78145-2.3306122056593-2.3131580710778-2.24340528213020.0248706915847110.2951924374040.29498218119429
1461Sema3b12.64363.851091.71506855473531.73252268931682.24315151755550.0248870454885290.294982181194290.29498218119429
1462Pappa26.988846.5072-0.7850932521244-0.76763911754289-2.23952438692050.0251218163781740.297561213557340.29756121355734
1463Abat12.62673.853921.71207910920271.72953324378432.23894346688220.0251595947790480.297804991653290.29780499165329
1464Tmem10011.95513.479771.78056234021041.79801647479192.23813127404890.0252124957540360.298227314872020.29822731487202
1465Nr4a13.2951611.8298-1.8440052593833-1.8265511248018-2.23697542091030.0252879465230370.298915610880150.29891561088015
1466Aplp14.8706214.6255-1.586308611436-1.5688544768545-2.23394677739280.0254865751979520.301057996386720.30105799638672
1467Arap125.769912.36381.05956471674321.07701885132472.23027342271110.0257292964666790.303717946089630.30371794608963
1468Gm49515.6088503.51450372574423.53195786032572.22984405541030.025757797502170.303847261134250.30384726113425
1469Tspan22.080599.41799-2.1784264944527-2.1609723598712-2.22843961680010.0258512137460120.304741639509660.30474163950966
1470Nupl117.793233.9856-0.93359759918632-0.91614346460481-2.22674737776150.0259641620843710.305864894432010.30586489443201
1471Mir81135.6189903.49031083276993.50776496735152.22588325342920.0260220023684770.306337875604980.30633787560498
1472Alg534.938156.6781-0.69799024220719-0.68053610762568-2.22512647592340.0260727488397950.306726760637720.30672676063772
1474Sh3d1929.409714.98970.972320557930260.989774692511772.22293414111760.0262202412041470.308043362911940.30804336291194
1475Snhg528.699548.5866-0.75953287624674-0.74207874166523-2.22264911112390.0262394698621380.308060270917050.30806027091705
1478Il11ra126.374812.84921.03748161487771.05493574945922.21850844020970.0265201847488910.310723977873170.31072397787317
1479Kcnab19.923062.442892.02219617438932.03965030897092.21824080598450.0265384178173150.310727370752160.31072737075216
1482Rbms232.101917.01170.916131369498530.933585504080042.21204336777740.0269636685526050.315067374038780.31506737403878
1488Nrip28.832181.921922.20022128944832.21767542402982.20629810414060.0273631340483770.318445828169180.31844582816918
1490Bok17.357333.1962-0.93547555633748-0.91802142175597-2.2045275186490.027487266837770.319461073711180.31946107371118
1491Syncrip39.296861.9369-0.65638734022902-0.63893320564751-2.19967310282390.0278300964569640.323228558246310.32322855824631
1492Ccna215.534730.6012-0.97809384711364-0.96063971253213-2.19857064380210.0279084662666740.32392152167560.3239215216756
1493Hrct111.31653.240681.80405935194171.82151348652322.19702661770790.0280185452620680.324981345146170.32498134514617
1495Gys111.47224.7332-1.1083319796197-1.0908778450382-2.19444335812270.0282035517560140.32668956906950.3266895690695
1497Irgm213.24694.354761.60498966782221.62244380240372.19157078993540.0284105130294860.32864719714870.32848948979402
1498Uqcrq40.882263.8404-0.64299685664401-0.6255427220625-2.1914969679110.028415848917910.328489489794020.32848948979402
1500Mir65385.4748103.45280889771583.47026303229732.18782198709770.0286825716493310.331020388704740.33091012208625
1501Mir65395.4748103.45280889771583.47026303229732.18782198709770.0286825716493310.331020388704740.33091012208625
1502G6pdx52.630432.99940.673456566186570.690910700768082.18615938167460.0288039467965060.332089178878220.33208917887822
1503Pdlim265.076543.09370.594659688115160.612113822696672.18332582897740.0290118237546340.334263308023290.33426330802329
1504Lxn48.091829.44540.707748653119060.725202787700572.18049382533270.0292208760419010.336448078735110.33644807873511
1507Tlr431.393716.69630.910946643888880.928400778470392.17731364666110.0294571736688110.338493614082820.33849361408282
1508Srgn5.2728203.57246032914653.5899144637282.17553432367670.0295900988847340.339795585137230.33979558513723
1511Mndal10.39452.803881.89032385127171.90777798585322.17262260407480.029808733189840.341626626504610.34162662650461
1512Snx3325.831112.70641.02355373966781.04100787424932.17177115805870.0298729281826560.342135910938520.34213591093852
1513Reck15.93946.057251.39586246172461.41331659630612.17141617965090.0298997269555780.342216504751980.34221650475198
1515Inhbb30.538716.13470.920471896074740.937926030656252.16591345109050.0303178012392270.346543474626860.34654347462686
1517Angpt422.135939.3597-0.83033119285349-0.81287705827198-2.16462901631370.0304161070542510.347208784349680.34720878434968
1518Galm17.64797.172081.29903303542671.31648717000832.16430393509570.0304410309286250.347264382471010.34726438247101
1519Ly6e49.242230.48410.691838265641590.70929240022312.16397155628560.0304665324442290.34732649265090.3473264926509
1523Tbc1d2b46.975128.75660.708003122191220.725457256772732.15568951534240.031107917416570.353707029483090.35370702948309
1525Acp56.064102.96190269683732.97935683141882.15236169991660.0313688777736350.356206463217080.35620646321708
1526C1qtnf76.2273902.87554245480872.89299658939022.14985810686820.0315664402528650.358214971073960.35821497107396
1528Epb4.1l338.13759.89-0.65112377202562-0.63366963744411-2.14715683639090.0317807977261710.360175441246140.36017544124614
1529Masp131.800517.17890.88841178848730.905865923068812.14655080964030.0318290596132550.360486478301340.36048647830134
1530Mapkapk239.562361.6718-0.64048465324628-0.62303051866477-2.14623560990830.0318541858669820.3605352527180.36051361767753
1533Ccpg120.74739.311451.1558458499541.17329998453552.14398375712380.0320341882783380.361863038757970.36186303875797
1534Ptprg19.63528.565451.19684134529691.21429547987842.14332603072590.032086928036540.362222511609370.36222251160937
1535Samd410.010222.2085-1.149641155128-1.1321870205465-2.14277516781570.0321311561984630.362485493087160.36248549308716
1536Mir81145.3056103.40751863113673.42497276571832.14238871954690.0321622148682870.362599658121180.36259965812118
1538Slc25a2427.529546.2503-0.74848431615963-0.73103018157812-2.1403576206570.0323258766493110.363970875121020.3638024890339
1541Gm241483.343211.4166-1.7718314939452-1.7543773593637-2.13729114696250.0325743184764640.366054168109620.36605416810962
15424930486L24Rik6.4300702.74887087746762.76632501204912.13527062444150.0327389109683550.367665188870950.36766518887095
1543Mut27.378914.01040.966566339093040.984020473674552.13446875939120.0328044283036920.368162206698020.36816220669802
1544Ppp1r15a11.444424.2461-1.0831108794388-1.0656567448573-2.13178997899790.033024115818360.3703877031260.370387703126
1545Dpt5.5192803.21034322196083.22779735654232.13088462422160.0330986483954830.370983361983540.37095233269763
1546Gnl330.945950.5719-0.70858770145366-0.69113356687214-2.13065831870290.0331173012848950.370952332697630.37095233269763
1547Ezh114.61225.378411.44192176321371.45937589779532.1297374408110.0331932960694960.371563224328030.37156322432803
1548Ggta136.227120.61440.813416850907230.830870985488742.12890123795240.0332624323449360.372096602659730.37192459548644
1550Cab39l32.189517.5820.872490977310760.889945111892262.1275455733020.033374778931440.372871643068230.37287164306823
1551Mrto426.392544.6323-0.75796013892635-0.74050600434484-2.1263440202290.0334746252312350.373746025228430.37374602522843
1552Ltbp235.214155.9545-0.66810095011015-0.65064681552864-2.12475114773770.0336073831110920.374986503437360.37497059712821
1553Nup8822.200239.0837-0.81599437795276-0.79854024337125-2.12425329770030.0336489686605630.375208750994830.37497059712821
1554Dclk133.907818.88930.844047943410780.861502077992292.12424976162020.0336492641876320.374970597128210.37497059712821
1555Fam214a17.46747.213791.27583555025371.29328968483522.12378635537130.0336880124696260.375160972306440.37516097230644
1556Kng217.7037.370781.26410466096121.28155879554272.12297917419420.0337555970401120.375672026956060.37567202695606
1557Cxcl16.4137716.5393-1.3666536517115-1.34919951713-2.12227011557430.0338150615244290.376092113306710.37609211330671
1559Utp11l33.229153.3977-0.68433038341853-0.66687624883702-2.12143564227750.0338851585016760.376388255146590.37614820816947
1560Pld111.35453.470961.70985753329961.72731166788112.12124593443250.0339011115593360.37632406979040.37614820816947
1562Mnda14.06425.073151.47107376859431.48852790317582.12041849791690.0339707680919990.376614462899580.37661446289958
1564Ggt57.424761.426692.37967250140082.39712663598232.11962575272120.0340376189197680.376873047847580.37687304784758
1566Camk2g25.673243.5982-0.76400544314755-0.74655130856604-2.11650400717670.0343019647579270.379314893814190.37920605893321
1569Pno123.766941.0818-0.78954565497203-0.77209152039052-2.11541733020740.0343943940284750.379609765067630.37947483958489
1570Pxylp119.269335.0694-0.86390858433677-0.84645444975527-2.11530356783080.0344040825863760.379474839584890.37947483958489
1571Adh15.7694703.00294918121033.02040331579182.1132621180180.0345783391657160.381154105240420.38115410524042
15721190002N15Rik25.833813.01440.989151069992841.00660520457442.11266688374110.0346292896506860.38147290641280.3814729064128
1573Aldh3b118.82478.154951.20687893699851.224333071582.11229352739730.0346612806843970.3815825795370.38157534710823
1574Mir218-15.4748114.9568-1.4499207415176-1.4324666069361-2.11204419889670.034682658448250.381575347108230.38157534710823
1576Yrdc11.091723.5695-1.0874406527045-1.069986518123-2.10879158496610.0349625752910230.384166825072740.38416682507274
1577C130074G19Rik5.933302.89404688802882.91150102261032.10514161944640.0352789823117220.387397677040010.38739767704001
1579As3mt10.51623.049031.78619123441521.80364536899672.1036430536780.0354095953689170.388339431921180.38833943192118
1581Dapk114.86915.637241.39925643105051.4167105656322.10104580612650.0356369454613480.390338383652230.39033838365223
15834930562F07Rik10.09182.825321.836697336571.85415147115152.10000326473040.0357285539374540.390847358518560.3907364678432
1585Galnt167.349691.433412.35823207586452.3756862104462.09780027542420.0359227921893960.392476335863580.39247633586358
1586Klhl2425.507912.86510.98748145930941.00493559389092.09642286237760.0360446960693190.393559900272630.39332166051206
1589Ak233.695253.7177-0.67285444598966-0.65540031140815-2.09533000931060.0361416665730680.39387365641650.3938736564165
1590Izumo420.01649.030731.1482680072281.16572214180962.09502807117530.0361684971777450.393918154482390.39391815448239
1591Magohb16.60831.2608-0.91247635023498-0.89502221565347-2.09403028529850.0362572824914020.394636933314650.39463693331465
1595Ctla2b8.898922.222452.00147929473572.01893342931722.08679508440670.0369066616762950.400697592632230.40069759263223
1596Mir118805.16722-3.3693883093777-3.3519341747962-2.08289335371050.0372609455741960.404290598062880.40429059806288
1598Gnpnat118.445333.6695-0.86818904330681-0.8507349087253-2.08158974688310.0373799587408290.405074308832880.40507430883288
1600Lnpep48.810230.80360.664083695433480.681537830014992.08013501804450.0375131504630390.406009516605280.40600951660528
1601Ttc39c15.94866.404061.31637105717121.33382519175272.07830946100040.0376808656118010.407569987382610.40743078141256
1602Zyx37.379258.1818-0.63833223806613-0.62087810348462-2.07819368549120.0376915234638170.407430781412560.40743078141256
1603Tbl1xr130.050416.2860.883751887298910.901206021880422.07759020180620.0377471194072720.407777209467080.40777720946708
1604Cd30249.879731.68640.654589028621110.672043163202622.07692169662580.0378087868866640.408188754686010.40797362313046
1605Dcaf628.250714.9610.917080006443820.934534141025332.07688234838340.0378124193061380.407973623130460.40797362313046
1606Trpm34.6217903.76731672868513.78477086326662.07606330197530.0378880967228470.408535598349650.40853559834965
1608Trafd136.875121.47120.780244137778620.797698272360132.07399199944690.0380800538962280.410094709776730.41009470977673
1609Nexn4.0615412.3621-1.6058250825931-1.5883709480115-2.07235322844110.0382325118013530.411480675490380.41148067549038
16104632428N05Rik9.613282.641131.86387344020781.88132757478932.06988102385340.0384634873805370.413709447806680.41370944780668
1612E030011O05Rik16.074130.3272-0.9158743430089-0.89842020842739-2.06913524616360.0385333970739970.413947169435730.41394716943573
1613Igf17.923981.76812.16402536607262.18147950065412.06861181166390.0385825286413660.414218008978630.41417162493504
1614Ube2c14.619428.304-0.95312185079644-0.93566771621493-2.06840319287670.0386021252321510.414171624935040.41417162493504
1615Jmjd614.650528.3444-0.95211382767385-0.93465969309234-2.06801014439250.0386390691943760.414311307268730.41424399585496
1617Ip6k131.440117.3880.854513805585270.871967940166782.06658766135730.0387730244440190.415233434939440.41523343493944
1618Fam160a117.01087.14281.25188935980111.26934349438262.06559176465640.03886704269940.415983052178930.41598305217893
1620Pole414.414827.9862-0.95716478922214-0.93971065464063-2.06419842662030.038998906640980.416879053272750.41687905327275
1621Pdk455.127836.04910.612816786892680.630270921474192.06261631300960.0391490966111450.418226345475140.41819243475909
1623Fam53b10.7083.274091.70952315902091.72697729360242.05969160130150.0394280328388140.420687150135390.4203524801289
1625Fat418.93658.451261.16393135042991.18138548501152.0595120221330.0394452145411710.42035248012890.4203524801289
1627Dusp42.9058210.2248-1.8150553803039-1.7976012457224-2.05702684382150.0396836437962650.4223734847080.42225701891953
1628Olfml2a6.615091.170982.49804434963922.51549848422072.05688711865250.0396970853381640.422257018919530.42225701891953
1629Sh3kbp126.586244.1886-0.73299663814692-0.71554250356541-2.05328648808780.040044800543710.425694174963430.42569417496343
1633Hist1h3d7.2460217.4227-1.2657075231153-1.2482533885337-2.05080125831920.0402863049796930.427212457644420.42721245764442
1634Ppp1r12a36.704457.0256-0.63565670219971-0.6182025676182-2.04952388152750.0404109150539780.428271613212810.42827161321281
1635Bmp8a5.1407303.18430032945613.20175446403762.04914541642590.0404478976077380.428401371787890.42840137178789
1636Calml410.68973.298121.6965055688731.71395970345452.04703104999930.0406550359772390.430332064803090.43033206480309
1637Fgf144.1470204.30696333590154.32441747048312.04634589484730.0407223512515950.430781280772060.43078128077206
1638Wnk44.0454404.528719724274.54617385885152.04467099685130.0408873048418190.432262184338080.43226218433808
1639Slfn59.447192.614621.8532839883761.87073812295752.04412009259350.0409416846629090.432573003848440.4323991623259
1641Slc25a3941.346662.7311-0.60141216171129-0.58395802712978-2.04262529502830.0410895451284810.433606126136450.43360612613645
1642Agtrap18.61578.307291.16407004279291.18152417737442.0421829938440.0411333827501560.433804378248750.43380437824875
1644Apbb227.836114.85480.906027914007210.923482048588722.04111027313580.0412398674945160.434398287957750.43420395041741
1646Iqsec114.2095.432251.38718324312851.404637377712.04064066104270.0412865574642290.434361674123970.43436167412397
1648Cacna1g7.59461.665922.18865485945352.2061089940352.03930412830650.0414196838873390.435233413760350.43522112883368
1649Sptssa48.208230.64640.653560951307960.671015085889472.03906393163040.0414436473665610.435221128833680.43522112883368
1650Hist1h2ak11.5723.7674-1.0385952259503-1.0211410913688-2.03813450682220.0415364830681860.435931683207140.43593168320714
1651Psd412.67384.493621.49589912001211.51335325459362.03766282267540.0415836646109960.43616251972660.43614601796957
1652Terc23.600811.79941.00012226332781.01757639790932.03742693120870.0416072773393620.436146017969570.43614601796957
1653Slc35f533.617819.21770.806789632729820.824243767311332.03677826490760.0416722673526030.436563008920160.43656300892016
1655Rarres29.274642.541811.86743509077021.88488922535182.03568906866050.0417815874601910.437179305165030.43717930516503
1657Abhd14b14.59185.694761.35745091332041.3749050479022.03462959335190.0418881573610240.437765371768770.43776537176877
1659Gclm11.043522.9649-1.0562330256224-1.0387788910409-2.0318147810180.0421724102575410.440204718764220.44020471876422
1660St6galnac631.016617.29090.843027584723510.860481719305022.02961876782450.0423953056962290.442264764302170.44226476430217
1661Rrn324.259440.9363-0.7548368420474-0.73738270746589-2.02890609172910.0424678561868570.442754885964960.44242328976105
1663Mcpt82.465349.26875-1.910588162267-1.8931340276855-2.02871676447650.0424871473622810.442423289761050.44242328976105
1665Ssfa217.8067.821851.18678168613291.20423582071442.02767203765110.0425937313449270.443000387807870.44300038780787
1666Wwp211.594423.7211-1.0327427486864-1.0152886141049-2.0265327311010.0427102220918180.443945327709490.44394532770949
1667Hist1h4f26.304743.5648-0.72784232344719-0.71038818886568-2.02586446977950.0427786751082160.444390112086970.44439011208697
1669Dhx587.536341.666612.17694751152592.19440164610742.02479008482340.042888923634740.445001492260510.44500149226051
1670Lbh15.652929.3955-0.90916534863784-0.89171121405633-2.02424286704990.0429451689105540.445318257499440.44531825749944
1671Slc7a14.6185713.0557-1.4991616727134-1.4817075381319-2.0237444613790.0429964513226120.445583212180540.44558321218054
1673Mcee26.203113.76310.928932043017940.946386177599452.02141051015420.0432372876156970.447543400861340.44742005362636
1674Irf712.21734.268491.51712778301341.5345819175952.02124326205230.0432545893338310.447455031955770.44742005362636
1675Cpxm117.62987.730641.1893563469451.20681048152652.02102627640570.0432770450900360.447420053626360.44742005362636
1676Ppan13.961127.0253-0.95289801650943-0.93544388192792-2.02073459718330.0433072463738380.447465146453310.44746514645331
1677Sfrp29.972452.964231.75029059160691.76774472618842.02028995583540.0433533200485920.447674086631760.44767408663176
1679Cxx1c13.3935.001681.42099449298861.43844862757012.01701513646090.0436939337395750.450653871690420.45049654835804
1680Efnb23.3926610.9136-1.6856383120544-1.6681841774729-2.01691202567970.0437046948802630.450496548358040.45049654835804
1681Tpx29.5404520.6637-1.1149693819752-1.0975152473937-2.01568439183790.0438329887508440.451550188101340.45155018810134
1682Bub332.542451.4261-0.66018009460245-0.64272596002094-2.01492171512650.0439128523171160.452103961697680.45210396169768
1683Gnl3l19.36734.3502-0.82671800505514-0.80926387047364-2.01445954815460.0439613078117730.452333908126250.45233390812625
1684Schip14.380212.5986-1.524194775449-1.5067406408675-2.01283761761050.0441317150492780.453817642225860.45381764222586
1687Fxr223.676340.0143-0.7570720290525-0.73961789447099-2.01122815110820.0443013635833910.454752052859260.45475205285926
1689Bdnf7.0486816.85-1.2573235756989-1.2398694411174-2.00617990797970.0448370567234510.459705927341620.45930192357059
1690Irf925.942313.65360.926025000158570.943479134740082.00615770106550.0448394252207440.459458181389120.45930192357059
1692Serpinb6c4.1846703.94698274793583.96443688251732.00579595953940.0448780219324030.45931010981290.4593101098129
1693Parp921.076310.16521.05198301984491.06943715442642.00539864307420.0449204466648340.459472755401610.45947275540161
1694Emilin135.127354.5741-0.63562374291066-0.61816960832915-2.00488841519760.0449749774733980.459758963935550.45975896393555
1695Aamdc29.237416.10350.860440738558410.877894873139922.00436495809660.0450309801611880.460059872242650.46005987224265
1696Gm1063811.14983.687111.59645546891041.61390960349192.00301149037830.0451760551663630.461269898181550.46124978037949
1697Cdk179.9108921.1225-1.0916940754916-1.0742399409101-2.00278174113140.0452007205234160.461249780379490.46124978037949
1698Gamt23.415711.8430.983441584895191.00089571947672.00193234966670.0452920078564940.461909128416320.46190912841632
1700Abhd531.678517.96870.818017987892990.83547212247452.00019491634570.0454792205546650.463272742555960.46327274255596
1701Rcan223.181411.68510.988297617388781.00575175197031.99987164399290.0455141258052630.463355741663570.46335574166357
1702Ereg10.829622.4243-1.0500829936559-1.0326288590744-1.99799860993030.0457168108261430.465145718611230.46506189054078
1703Pcmtd215.13836.176481.29334642281041.31080055739191.99782692146920.0457354275908610.465061890540780.46506189054078
1704Hebp130.673617.22450.832535393731610.849989528313121.99738255731050.0457836411710510.465278940234210.46527894023421
1705Sorbs212.74884.670071.44884537776661.46629951234811.99635197113630.0458956247634980.466143421718180.46614342171818
1707Ppapdc1b23.540439.6819-0.75334226977854-0.73588813519703-1.99404515562860.0461471199723160.468148609584420.46814860958442
1708Egln19.9254421.0714-1.0860832068869-1.0686290723054-1.99184531031130.0463880330566110.470317077541760.47004634530331
1709Aurka6.5061215.9231-1.2912518982784-1.2737977636969-1.99184129283140.0463884739922250.470046345303310.47004634530331
17101110008P14Rik38.680123.43240.723086798737260.740540933318771.99157499836290.0464177088193530.470067522587570.47006752258757
1711Prkar2b24.642612.78870.946284861942390.96373899652391.99024375358320.0465640906524040.471274317842020.47127431784202
1712Acvr1b9.260552.646331.80710490182071.82455903640221.98972801224230.0466209051842550.47157372375920.4712907756102
1713Ikbkg12.669624.9866-0.97978362607613-0.96232949149462-1.98957322166730.0466379684326860.4714709278160.4712907756102
1714Ruvbl216.897930.8218-0.86710715245494-0.84965301787343-1.98945483160490.0466510226389950.47132774739760.4712907756102
1715Mphosph611.330323.0834-1.0266696761885-1.009215541607-1.98924126914250.046674578747560.47129077561020.4712907756102
1719Cth2.348678.84795-1.9134992112398-1.8960450766583-1.98417662855920.0472361530122330.475851344800950.47576927389482
1720Rrp913.57826.2189-0.94933616888786-0.93188203430635-1.9840032266650.0472554802274690.475769273894820.47576927389482
1721Best14.5888603.36995918660743.38741332118891.98344730370640.0473174877334740.476116754840540.47611675484054
1722Nek935.123520.72640.760967059958530.778421194540041.98182745312240.0474985557373140.477661143846140.47750162982573
1723Galnt93.7482706.96703862930796.98449276388941.98172285448980.0475102678402570.477501629825730.47750162982573
1726Slc6a129.148642.611361.80875593395261.82621006853411.97889220740850.0478281438115520.479860930697940.47986093069794
1728Ccdc4724.351240.5747-0.73658755939402-0.71913342481251-1.97617415103640.0481350564496550.482381234108030.48238123410803
1729Antxr154.751236.48980.585397341524490.6028514761061.97549776734710.0482116877287530.482869749218520.48286974921852
1731Mturn8.74622.402681.86401182252531.88146595710681.97442531982610.0483334013544550.483529469240380.48335220343802
1732Mzt119.910634.7368-0.80292816029376-0.78547402571225-1.97433561347630.0483435939455250.483352203438020.48335220343802
1733Fbl32.092450.4367-0.65224220106548-0.63478806648397-1.97351237227570.0484372163760330.48400881476270.4840088147627
1734Pygl25.428213.45530.918254783060660.935708917642171.97247632647440.0485552561997850.484908518807190.48490851880719
1736Kcnj22.10318.31194-1.9826677899402-1.9652136553587-1.96954438303330.048890611156780.487695111406660.48769511140666
1737Dysf9.9782920.9876-1.0726726949613-1.0552185603798-1.9675010878750.0491254706243370.489755771330830.48975577133083
1739Pxmp417.9588.187331.13316173352551.1506158681071.96380204746420.0495530525691910.493450380299420.49339804241309
1741Gusb49.912732.63570.612955963882060.630410098463571.96301254469720.0496447164076080.493795263659130.49379526365913
1742Edil316.660130.2809-0.86201102500682-0.84455689042531-1.96182478141710.0497828874743070.494885340064620.49488534006462
GeneNamesvalue1value2log2.Fold_change.log2.Fold_change..normalizedz.scorep.valueq.value.Benjamini.et.al..1995.q.value.Storey.et.al..2003.Signature.p.value…0.001.
1Rn45s11920.63591214.1383183.29545650577093.4764390155395105.837831260730001
2Col1a210892.696754788.5353761.18570480719231.366687316960957.6442061845180001
3Col1a115645.400879729.1995050.685345610567120.8663281203357848.1585673543380001
4Fn12070.6992536750.367655-1.7048480471892-1.5238655374206-45.986098515690001
5Col3a12705.8830731026.3033131.3986423316231.579624841391731.7200838856928.21E-2212.21E-2172.21E-2171
6Sfrp2849.970052349.284686834.10820064671384.289183156482530.1148959943953.09E-1996.93E-1966.93E-1961
7Matn4656.474240523.636533484.79564803074054.976630540509227.255780728011.42E-1632.73E-1602.73E-1601
8Lum709.523852159.217059943.58276641502443.763748924793126.4455244699494.11E-1546.91E-1516.91E-1511
9Ptn614.59915940.735302383.91529427025564.096276780024325.285758910194.58E-1416.85E-1386.85E-1381
10Thbs13574.4381336670.154313-0.90000365627761-0.71902114650894-24.8423418531373.13E-1364.21E-1334.21E-1331
11Cxcl12508.970442320.116198714.6611522615584.842134771326723.9002969615023.04E-1263.72E-1233.72E-1231
12Gas6767.7490356134.65280512.51139051046342.69237302023223.6974733961283.83E-1244.29E-1214.29E-1211
13Col2a1285.36221241254.244989-2.1359529629909-1.9549704532222-23.4819019835926.24E-1226.46E-1196.46E-1191
14Lars2546.140458446.770161993.54561170575143.7265942155223.119448997632.95E-1182.84E-1152.84E-1151
15Lyz2541.082513249.661865563.44563825396753.626620763736222.7862921189616.27E-1155.62E-1125.62E-1121
16Igfbp41512.443251610.52663081.30875488027651.489737390045122.6909956076625.50E-1144.62E-1114.62E-1111
17Acta2455.09744431522.670516-1.7423564074689-1.5613738977002-22.1306396261341.60E-1081.27E-1051.27E-1051
18Apoe367.93610916.218685214.50372649301854.684709002787220.2031925684949.18E-916.86E-886.86E-881
19Serpine134.22935029473.3593008-3.7896298553825-3.6086473456138-19.9786695566738.44E-895.98E-865.98E-861
20Dcn401.459699538.849408753.36929062267893.550273132447619.4689009438182.02E-841.36E-811.36E-811
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22Gpx3322.296975312.069719224.73892662909614.919909138864819.0645073333764.98E-813.04E-783.04E-781
23Sparc4138.9283463005.9887180.461417677965440.642400187734118.8233299164244.86E-792.84E-762.84E-761
24Flna478.15226441367.775786-1.5162897412942-1.3353072315255-18.6538987285741.17E-776.58E-756.58E-751
25Hspg2302.41807421041.390462-1.7838948275951-1.6029123178265-18.6460985338831.36E-777.31E-757.31E-751
26Lox570.60679821487.592894-1.3824109211694-1.2014284114008-17.9173508076118.63E-724.47E-694.47E-691
27Fmod1078.518601479.64561291.16901029211021.349992801878917.7827964613659.61E-714.79E-684.79E-681
28Penk215.49199222.7659773226.28370112074076.464683630509415.6718877835352.35E-551.13E-521.13E-521
29Postn384.050957785.996749472.15894371270432.339926222472915.480393719284.71E-542.18E-512.18E-511
30Mir6236243.251877723.887985963.34809381367843.529076323447115.1185330800651.22E-515.48E-495.48E-491
31Abi3bp246.6630526.025332083.24455313947273.425535649241315.0451294238743.72E-511.61E-481.61E-481
32Igfbp5432.2778774125.47478941.7845614809581.965543990726714.7217654501724.67E-491.96E-461.96E-461
33Fth1794.6855346371.26959241.09791692286681.278899432635414.6358535613571.66E-486.76E-466.76E-461
34Cst3335.588784872.921220312.20228389281032.38326640257914.6279232581541.86E-487.37E-467.37E-461
35Col5a1849.02903921737.410937-1.0330532204358-0.85207071066714-14.5966936803182.95E-481.13E-451.13E-451
36Slc7a511.6450367229.198939-4.2988132742304-4.1178307644618-14.5221080746998.78E-483.28E-453.28E-451
37Gpnmb233.959373628.162678193.05440158976583.235384099534514.3028475911462.10E-467.63E-447.63E-441
38Myh9330.2955863879.2036098-1.4124396184677-1.2314571086991-14.0370189124569.25E-453.27E-423.27E-421
39Islr229.254308331.557286722.86090377257763.041886282346213.7655318382694.11E-431.42E-401.42E-401
40Col14a1181.733148513.326981643.76939962021183.950382129980513.5972699122474.16E-421.40E-391.40E-391
41Sfrp1158.67832837.9207532414.32432366043714.505306170205813.1615491928991.46E-394.79E-374.79E-371
42Ogn334.88302595.551943861.80930012057061.990282630339313.0634556445475.33E-391.71E-361.71E-361
43Egfl6143.50449264.7775971934.90866686992665.089649379695212.7779721343812.18E-376.81E-356.81E-351
44Cemip238.5468123663.2059261-1.4751844904202-1.2942019806516-12.6712099087078.54E-372.61E-342.61E-341
45Pcolce444.9815538174.633751.3494131285681.530395638336712.5415157931864.42E-361.32E-331.32E-331
46Kctd12312.651591390.522894181.78820124412551.969183753894212.5341202251034.86E-361.42E-331.42E-331
47Fbln290.80776091373.2812123-2.0393753896398-1.8583928798711-12.3748816988233.57E-351.02E-321.02E-321
48Ibsp182.438908309.50291192172039.68389443148912.364751295854.05E-351.14E-321.14E-321
49Cpxm2174.087417320.744829923.06898819737393.249970707142612.3616759591384.21E-351.16E-321.16E-321
50Flnb112.4510614412.0048948-1.8733641989137-1.6923816891451-12.1856845945313.71E-349.97E-329.97E-321
51Cpxm1134.32961528.2979319674.01688176684194.197864276610611.9007425885451.17E-323.09E-303.09E-301
52Clec11a236.900039557.58261882.0405731312932.221555641061711.7811816983314.88E-321.26E-291.26E-291
53Itm2b379.463519146.84825061.36963511500311.550617624771811.6926741060811.39E-313.53E-293.53E-291
54Ctsb512.9697478243.28027811.07625437527341.257236885042111.5996992282894.14E-311.03E-281.03E-281
55Psap669.5307968366.74344770.868379226867051.049361736635711.4692807033661.88E-304.60E-284.60E-281
56Chrdl1117.74425995.909133374.31656635800234.49754886777111.3330608848039.00E-302.16E-272.16E-271
57Atf552.93198499261.7620357-2.3060442108771-2.1250617011084-11.3134719480221.13E-292.66E-272.66E-271
581500015O10Rik124.21372488.8008369343.81904005408134.000022563849911.2848519962251.56E-293.62E-273.62E-271
59Rcn3373.1116808150.36858531.3111043329411.492086842709711.2704970890951.84E-294.18E-274.18E-271
60Nov257.719953676.818733811.74627415064571.927256660414411.218306257563.32E-297.43E-277.43E-271
61Tubb5229.2543083592.5477782-1.3699826396504-1.1890001298817-11.2055348420033.83E-298.44E-278.44E-271
62Eef2600.4839631170.511312-0.96294125514002-0.78195874537135-11.1228645272679.71E-292.11E-262.11E-261
63Adam23195.142584742.872648492.18639919369272.367381703461411.1096789852961.13E-282.40E-262.40E-261
64Ccnd2232.3126008593.4278619-1.3530052549936-1.1720227452249-11.0863492590531.46E-283.07E-263.07E-261
65Ctgf79.63323075312.9326161-1.9744095399265-1.7934270301579-11.0577234238492.01E-284.16E-264.16E-261
66Itgb1307.5936461716.136674-1.2192092485903-1.0382267388216-11.0432080435722.36E-284.82E-264.82E-261
67H2-K1147.150918320.619103672.83524302149143.016225531260110.9836618482314.58E-289.19E-269.19E-261
68Thbs2979.5946022641.95819120.609705482297760.7906879920664210.9376936147057.61E-281.51E-251.51E-251
69Ptx3148.6800645441.9277404-1.5715992746712-1.3906167649025-10.9275251696238.51E-281.66E-251.66E-251
70Tnmd214.668605855.696725171.94644681149242.127429321261110.9160897132329.66E-281.86E-251.86E-251
71Actb436.6300628911.8924327-1.0624521873661-0.88146967759741-10.8740811030211.53E-272.90E-252.90E-251
72Piezo197.04197248338.4550433-1.8022834343912-1.6213009246225-10.711259756959.01E-271.68E-241.68E-241
73Flnc72.69325938288.0388202-1.9863697640011-1.8053872542324-10.6572056810831.61E-262.97E-242.97E-241
74Pgm5110.45140878.0464794833.77891029923453.959892809003110.6080492293052.73E-264.97E-244.94E-241
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77Lgr5116.803246910.812456813.43331410377743.61429661354610.5713475506074.05E-267.07E-247.07E-241
78Gdf10119.155779512.446897953.25899078952583.439973299294510.4740081672291.14E-251.96E-231.96E-231
79Comp108.92226248.5493844513.67133449265483.852317002423510.4410260764371.61E-252.74E-232.74E-231
80Hspa953.99062469239.0055859-2.1462635219606-1.9652810121919-10.2783069793068.83E-251.48E-221.48E-221
81Mest250.19184985.619570751.54702228093241.728004790701110.2587469250831.08E-241.79E-221.79E-221
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83Fkbp9428.3961985212.60307511.01078321374221.191765723510810.1622356682552.92E-244.74E-224.74E-221
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85Aspn205.964234963.86893091.68920763269181.87019014246059.82815976619688.52E-231.35E-201.35E-201
86Marcks452.8625382238.87985960.922787978718651.10377048848739.82603880651728.70E-231.36E-201.36E-201
87Timp3169.6176052442.9335503-1.3848043592706-1.2038218495019-9.78228148699791.34E-222.07E-202.07E-201
88Stab1100.80602479.9323731123.3432995965373.52428210630579.72667947144722.32E-223.55E-203.55E-201
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91Gas1169.499978645.638625821.89295783340142.07394034317019.54376046280141.38E-212.04E-192.04E-191
92Mgp267.7182174109.50755671.2896848851131.47066739488169.44386704999693.59E-215.25E-195.25E-191
93Ahnak216.7858852510.0713635-1.2344282802816-1.053445770513-9.42960223208234.12E-215.95E-195.95E-191
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95Col16a1250.427102398.820826151.3415036833991.52248619316779.3708969020227.19E-211.02E-181.02E-181
96Itgbl196.5714659411.063909293.12573574420873.30671825397749.27569220045811.76E-202.47E-182.47E-181
97Htra1172.91115151.044854221.76019347412721.94117598389599.23231230189152.65E-203.67E-183.67E-181
98Ctsd869.7313267610.77808330.509921504752780.690904014521459.16163610615235.11E-207.01E-187.01E-181
99Asns10.82165026110.6390929-3.3538688068898-3.1728862971212-9.15727226728445.32E-207.23E-187.23E-181
100H191048.170929772.71348280.439868525171770.620851034940449.15073542774245.65E-207.61E-187.61E-181
101B2m266.3066978114.66233261.21569718029871.39667969006749.06055598898711.30E-191.73E-171.73E-171
102Marco77.2806980807.6787160099127.85969851968078.95986552003583.25E-194.29E-174.29E-171
103Bst287.749468459.806646873.16155855268593.34254106245458.88230099585866.55E-198.55E-178.55E-171
104Sepp173.516645824.4004184674.06235831401064.24334082377938.82932530930791.05E-181.36E-161.36E-161
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106Emilin1208.552020880.716247311.3694762847341.55045879450278.66623543587934.47E-185.67E-165.67E-161
107Cdh11536.3774479336.31769710.67342388436390.854406394132568.64467377610425.40E-186.78E-166.78E-161
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109Olfml3107.510742822.630723552.24812620915552.42910871892428.3705834150645.73E-177.07E-157.07E-151
110Mpeg179.280350859.4294681443.07171504198493.25269755175368.34474331054577.14E-178.73E-158.73E-151
111Ctss67.635314154.7775971933.82341958362284.00440209339148.32977211837238.10E-179.81E-159.81E-151
112Mrc164.459395053.7717872584.09507043842824.27605294819698.28417895230371.19E-161.43E-141.43E-141
113Fat1298.654022596.1938392-0.99730631643049-0.81632380666182-8.23244028443941.83E-162.18E-142.18E-141
114Myo1c85.63218905252.58402-1.5605382571145-1.3795557473458-8.20990807242982.21E-162.61E-142.61E-141
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116Unc5b40.93406839165.2042819-2.0128771133733-1.8318946036047-8.15118647428723.60E-164.18E-144.18E-141
117Epyc57.519423691.6344411455.13717988812725.31816239789598.12459169879714.49E-165.16E-145.16E-141
118Lpl83.3972830113.326981642.64565031425592.82663282402468.00756639703161.17E-151.33E-131.33E-131
119Ipo531.05343119141.1905697-2.1848191421481-2.0038366323795-8.00062523538961.24E-151.40E-131.40E-131
120Lgals3bp137.858414243.50127971.66405757783331.8450400876027.96673068100061.63E-151.83E-131.83E-131
121Fbn1127.977777319.7218332-1.3209239545775-1.1399414448089-7.95674581916741.77E-151.96E-131.96E-131
122Alpl69.164460387.4178482733.2209582467143.40194075648277.9436457761341.96E-152.16E-132.16E-131
123Lgmn103.040930823.762259722.11647358715722.29745609692587.92944710628222.20E-152.41E-132.41E-131
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572Sema3d21.878553795.5319546451.98365614327792.16463865304663.52252924366380.000427449880493150.0100503032215950.0100503032215951
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5853632451O06Rik17.29111513.268882292.40316157826222.58414408803083.47628038821660.000508420434833320.0116884554326040.0116884554326041
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601Tril11.292156803.90392895068424.08491146045293.42381676054190.000617482416809850.0138178386417230.0138178386417231
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612Smpdl3a23.172446766.7892170641.7710932684121.95207577818073.39188032004550.00069414753024930.0152542322456260.0152542322456261
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626Hp9.76301056406.27896838163716.45995089140583.33595160553830.000850079603670570.0182631319325330.0182631319325331
627Ctsf29.1714050610.812456811.43186050630611.61284301607483.33474064624650.000853789895388840.0183135890001350.0183135890001351
628Bace215.409088962.7659773222.47792033400342.6589028437723.33311797195230.000858785199553870.0183914046955410.0183914046955411
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631Stat230.2300447611.566814261.38599154400181.56697405377053.32449068146540.000885801936428140.0188797943629510.0188797943629511
632Lcp128.1127653610.18382561.46494575572151.64592826549023.32172357739310.000894632757047370.0190378416922940.0190378416922941
633Hcfc1r133.5235904913.829886611.27738734682451.45836985659313.32018349829220.000899582979406160.0191129407425490.0191129407425491
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635Mdm226.2307392362.10876351-1.2435383802808-1.0625558705121-3.31213229828760.000925877497312730.0196096479706440.0196096479706441
636Lims145.7567603692.40878781-1.0140451433268-0.83306263355813-3.2961105441180.000980334325560770.0207303716107970.0206990497109561
637Slc44a281.2800036151.673485430.653476267870050.834458777638723.29609396049050.000980392197626530.0206990497109560.0206990497109561
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639Tmed356.6960372531.431560480.851034002745981.03201651251463.28989946346680.00100223185173760.0210939220250690.021093922025069
640Lifr26.113112599.0522894181.52841981599581.70940232576443.28848945086960.00100726559195480.0211667421034380.021166742103438
641Utp2012.8213030338.84940875-1.5993497517785-1.4183672420099-3.28753585177820.00101068319268840.021205426300260.02120542630026
642C4b10.233517104.02494435164564.20592686141423.28629096761040.00101516088213850.021266197358070.02126619735807
643Nenf30.1124181311.69254051.36477014015681.54575264992553.28513975216440.00101931799183380.0213200741402370.021320074140237
644Masp18.233864331